Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats

Behavioral and biochemical evidence

Jean Lud Cadet, Mindy Joy Katz, Vernice Jackson-Lewis, Stanley Fahn

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

Unilateral 6-hydroxydopamine (6-OHDA) injections into the striatum lead to the development of apomorphine-induced rotation in rats. The circling behavior was associated with significant decreases in dopamine, dihydroxyphenylacetic acid and homovanillic acid in the ipsilateral striatum. Pretreatments with either d-a-tocopherol or all-racemic-a-tocopherol caused significant attenuation of both the behavioral and biochemical abnormalities. These results are discussed in terms of their support for the three radical hypothesis of Parkinson's disease and for the role of antioxidants in the treatment of this neurodegenerative disorder.

Original languageEnglish (US)
Pages (from-to)10-15
Number of pages6
JournalBrain Research
Volume476
Issue number1
DOIs
StatePublished - Jan 2 1989
Externally publishedYes

Fingerprint

Tocopherols
Poisons
Oxidopamine
Vitamin E
Homovanillic Acid
Injections
Apomorphine
Neurodegenerative Diseases
Parkinson Disease
Dopamine
Antioxidants
Acids
Therapeutics

Keywords

  • 6-Hydroxydopamine
  • Antioxidant
  • Free radical
  • Parkinson's disease
  • Rotation
  • Striatum
  • α-Tocopherol

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats : Behavioral and biochemical evidence. / Cadet, Jean Lud; Katz, Mindy Joy; Jackson-Lewis, Vernice; Fahn, Stanley.

In: Brain Research, Vol. 476, No. 1, 02.01.1989, p. 10-15.

Research output: Contribution to journalArticle

@article{c77a900e666e4ae59b3ecfc464197f68,
title = "Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats: Behavioral and biochemical evidence",
abstract = "Unilateral 6-hydroxydopamine (6-OHDA) injections into the striatum lead to the development of apomorphine-induced rotation in rats. The circling behavior was associated with significant decreases in dopamine, dihydroxyphenylacetic acid and homovanillic acid in the ipsilateral striatum. Pretreatments with either d-a-tocopherol or all-racemic-a-tocopherol caused significant attenuation of both the behavioral and biochemical abnormalities. These results are discussed in terms of their support for the three radical hypothesis of Parkinson's disease and for the role of antioxidants in the treatment of this neurodegenerative disorder.",
keywords = "6-Hydroxydopamine, Antioxidant, Free radical, Parkinson's disease, Rotation, Striatum, α-Tocopherol",
author = "Cadet, {Jean Lud} and Katz, {Mindy Joy} and Vernice Jackson-Lewis and Stanley Fahn",
year = "1989",
month = "1",
day = "2",
doi = "10.1016/0006-8993(89)91530-8",
language = "English (US)",
volume = "476",
pages = "10--15",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats

T2 - Behavioral and biochemical evidence

AU - Cadet, Jean Lud

AU - Katz, Mindy Joy

AU - Jackson-Lewis, Vernice

AU - Fahn, Stanley

PY - 1989/1/2

Y1 - 1989/1/2

N2 - Unilateral 6-hydroxydopamine (6-OHDA) injections into the striatum lead to the development of apomorphine-induced rotation in rats. The circling behavior was associated with significant decreases in dopamine, dihydroxyphenylacetic acid and homovanillic acid in the ipsilateral striatum. Pretreatments with either d-a-tocopherol or all-racemic-a-tocopherol caused significant attenuation of both the behavioral and biochemical abnormalities. These results are discussed in terms of their support for the three radical hypothesis of Parkinson's disease and for the role of antioxidants in the treatment of this neurodegenerative disorder.

AB - Unilateral 6-hydroxydopamine (6-OHDA) injections into the striatum lead to the development of apomorphine-induced rotation in rats. The circling behavior was associated with significant decreases in dopamine, dihydroxyphenylacetic acid and homovanillic acid in the ipsilateral striatum. Pretreatments with either d-a-tocopherol or all-racemic-a-tocopherol caused significant attenuation of both the behavioral and biochemical abnormalities. These results are discussed in terms of their support for the three radical hypothesis of Parkinson's disease and for the role of antioxidants in the treatment of this neurodegenerative disorder.

KW - 6-Hydroxydopamine

KW - Antioxidant

KW - Free radical

KW - Parkinson's disease

KW - Rotation

KW - Striatum

KW - α-Tocopherol

UR - http://www.scopus.com/inward/record.url?scp=0024500857&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024500857&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(89)91530-8

DO - 10.1016/0006-8993(89)91530-8

M3 - Article

VL - 476

SP - 10

EP - 15

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -