Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats: Behavioral and biochemical evidence

Jean Lud Cadet, Mindy Katz, Vernice Jackson-Lewis, Stanley Fahn

Research output: Contribution to journalArticle

140 Scopus citations

Abstract

Unilateral 6-hydroxydopamine (6-OHDA) injections into the striatum lead to the development of apomorphine-induced rotation in rats. The circling behavior was associated with significant decreases in dopamine, dihydroxyphenylacetic acid and homovanillic acid in the ipsilateral striatum. Pretreatments with either d-a-tocopherol or all-racemic-a-tocopherol caused significant attenuation of both the behavioral and biochemical abnormalities. These results are discussed in terms of their support for the three radical hypothesis of Parkinson's disease and for the role of antioxidants in the treatment of this neurodegenerative disorder.

Original languageEnglish (US)
Pages (from-to)10-15
Number of pages6
JournalBrain Research
Volume476
Issue number1
DOIs
StatePublished - Jan 2 1989
Externally publishedYes

Keywords

  • 6-Hydroxydopamine
  • Antioxidant
  • Free radical
  • Parkinson's disease
  • Rotation
  • Striatum
  • α-Tocopherol

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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