Vitamin D metabolism-related genetic variants, dietary protein intake and improvement of insulin resistance in a 2 year weight-loss trial

POUNDS Lost

Qibin Qi, Yan Zheng, Tao Huang, Jennifer Rood, George A. Bray, Frank M. Sacks, Lu Qi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aims/hypothesis: Vitamin D and related genetic variants are associated with obesity and insulin resistance. We aimed to examine whether vitamin D metabolism-related variants affect changes in body weight and insulin resistance in response to weight-loss diets varying in macronutrient content. Methods: Three vitamin D metabolism-related variants, DHCR7 rs12785878, CYP2R1 rs10741657 and GC rs2282679, were genotyped in 732 overweight/obese participants from a 2 year weight-loss trial (POUNDS Lost). We assessed genotype effects on changes in body weight, fasting levels of glucose and insulin, and HOMA-IR at 6 months (up to 656 participants) and 2 years (up to 596 participants) in response to low-protein vs high-protein diets, and low-fat vs high-fat diets. Results: We found significant interactions between DHCR7 rs12785878 and diets varying in protein, but not in fat, on changes in insulin and HOMA-IR at both 6 months (p for interaction

Original languageEnglish (US)
Pages (from-to)2791-2799
Number of pages9
JournalDiabetologia
Volume58
Issue number12
DOIs
StatePublished - Sep 29 2015

Fingerprint

Dietary Proteins
Vitamin D
Insulin Resistance
Weight Loss
Body Weight Changes
Insulin
Reducing Diet
Protein-Restricted Diet
Fat-Restricted Diet
High Fat Diet
Fasting
Proteins
Obesity
Fats
Genotype
Diet
Glucose

Keywords

  • Diet intervention
  • Genetic variants
  • Insulin resistance
  • Vitamin D
  • Weight loss

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Vitamin D metabolism-related genetic variants, dietary protein intake and improvement of insulin resistance in a 2 year weight-loss trial : POUNDS Lost. / Qi, Qibin; Zheng, Yan; Huang, Tao; Rood, Jennifer; Bray, George A.; Sacks, Frank M.; Qi, Lu.

In: Diabetologia, Vol. 58, No. 12, 29.09.2015, p. 2791-2799.

Research output: Contribution to journalArticle

Qi, Qibin ; Zheng, Yan ; Huang, Tao ; Rood, Jennifer ; Bray, George A. ; Sacks, Frank M. ; Qi, Lu. / Vitamin D metabolism-related genetic variants, dietary protein intake and improvement of insulin resistance in a 2 year weight-loss trial : POUNDS Lost. In: Diabetologia. 2015 ; Vol. 58, No. 12. pp. 2791-2799.
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