Vitamin D intake and lung cancer risk in the Women's Health Initiative

Ting Yuan David Cheng, Andrea Z. LaCroix, Shirley A A Beresford, Gary E. Goodman, Mark D. Thornquist, Yingye Zheng, Rowan T. Chlebowski, Gloria Y F Ho, Marian L. Neuhouser

Research output: Contribution to journalArticle

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Abstract

Background: Prior research suggests that vitamin D protects against lung cancer only among certain subgroups Objectives: We investigated whether vitamin D intake was associated with lung cancer and explored whether vitamin A intake modified the association Design: Prospective cohort data from 128,779 postmenopausal women, including 1771 incident lung cancers in the Women's Health Initiative (Clinical Trials and Observational Study) 1993-2010, were analyzed. Twelve percent of women received active intervention (1 g Ca + 400 IU vitamin D3/d) in the Calcium/Vitamin D Trial Baseline total intake included both dietary intake (from food-frequency questionnaires) and supplement intake (from bottle labels). HRs were estimated by Cox proportional hazard models Results: No significant association was observed overall. Among never smokers, a total vitamin D intake $400 IU/d was significantly associated with lower risks of lung cancer (HR: 0.37; 95% CI: 0.18, 0.77 for $800 compared with ,100 IU/d; P-trend = 0.01). No significant effect modification of total vitamin A intake on the association between total vitamin D intake and lung cancer was found However, the Calcium/Vitamin D Trial active intervention was significantly associated with a lower lung cancer risk only among women with a vitamin A intake ,1000 mg/d retinol activity equivalents (HR: 0.69; 95% CI: 0.50, 0.96; P-interaction = 0.09) Conclusions: Vitamin D intake was associated with a lower lung cancer risk in never-smoking, postmenopausal women. Lower vitamin A intake may be important for a beneficial association of 1 g Ca + 400 IU vitamin D3 supplementation with lung cancer.

Original languageEnglish (US)
Pages (from-to)1002-1011
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Volume98
Issue number4
DOIs
StatePublished - Oct 1 2013

Fingerprint

Women's Health
Vitamin D
Lung Neoplasms
Vitamin A
Cholecalciferol
Calcium
Proportional Hazards Models
Observational Studies
Eating
Smoking
Clinical Trials
Research

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Cheng, T. Y. D., LaCroix, A. Z., Beresford, S. A. A., Goodman, G. E., Thornquist, M. D., Zheng, Y., ... Neuhouser, M. L. (2013). Vitamin D intake and lung cancer risk in the Women's Health Initiative. American Journal of Clinical Nutrition, 98(4), 1002-1011. https://doi.org/10.3945/ajcn.112.055905

Vitamin D intake and lung cancer risk in the Women's Health Initiative. / Cheng, Ting Yuan David; LaCroix, Andrea Z.; Beresford, Shirley A A; Goodman, Gary E.; Thornquist, Mark D.; Zheng, Yingye; Chlebowski, Rowan T.; Ho, Gloria Y F; Neuhouser, Marian L.

In: American Journal of Clinical Nutrition, Vol. 98, No. 4, 01.10.2013, p. 1002-1011.

Research output: Contribution to journalArticle

Cheng, TYD, LaCroix, AZ, Beresford, SAA, Goodman, GE, Thornquist, MD, Zheng, Y, Chlebowski, RT, Ho, GYF & Neuhouser, ML 2013, 'Vitamin D intake and lung cancer risk in the Women's Health Initiative', American Journal of Clinical Nutrition, vol. 98, no. 4, pp. 1002-1011. https://doi.org/10.3945/ajcn.112.055905
Cheng TYD, LaCroix AZ, Beresford SAA, Goodman GE, Thornquist MD, Zheng Y et al. Vitamin D intake and lung cancer risk in the Women's Health Initiative. American Journal of Clinical Nutrition. 2013 Oct 1;98(4):1002-1011. https://doi.org/10.3945/ajcn.112.055905
Cheng, Ting Yuan David ; LaCroix, Andrea Z. ; Beresford, Shirley A A ; Goodman, Gary E. ; Thornquist, Mark D. ; Zheng, Yingye ; Chlebowski, Rowan T. ; Ho, Gloria Y F ; Neuhouser, Marian L. / Vitamin D intake and lung cancer risk in the Women's Health Initiative. In: American Journal of Clinical Nutrition. 2013 ; Vol. 98, No. 4. pp. 1002-1011.
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abstract = "Background: Prior research suggests that vitamin D protects against lung cancer only among certain subgroups Objectives: We investigated whether vitamin D intake was associated with lung cancer and explored whether vitamin A intake modified the association Design: Prospective cohort data from 128,779 postmenopausal women, including 1771 incident lung cancers in the Women's Health Initiative (Clinical Trials and Observational Study) 1993-2010, were analyzed. Twelve percent of women received active intervention (1 g Ca + 400 IU vitamin D3/d) in the Calcium/Vitamin D Trial Baseline total intake included both dietary intake (from food-frequency questionnaires) and supplement intake (from bottle labels). HRs were estimated by Cox proportional hazard models Results: No significant association was observed overall. Among never smokers, a total vitamin D intake $400 IU/d was significantly associated with lower risks of lung cancer (HR: 0.37; 95{\%} CI: 0.18, 0.77 for $800 compared with ,100 IU/d; P-trend = 0.01). No significant effect modification of total vitamin A intake on the association between total vitamin D intake and lung cancer was found However, the Calcium/Vitamin D Trial active intervention was significantly associated with a lower lung cancer risk only among women with a vitamin A intake ,1000 mg/d retinol activity equivalents (HR: 0.69; 95{\%} CI: 0.50, 0.96; P-interaction = 0.09) Conclusions: Vitamin D intake was associated with a lower lung cancer risk in never-smoking, postmenopausal women. Lower vitamin A intake may be important for a beneficial association of 1 g Ca + 400 IU vitamin D3 supplementation with lung cancer.",
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