Abstract
Purpose of review: To discuss the role of vitamin D in asthma, allergic rhinitis, and chronic rhinosinusitis (CRS). Recent findings: Over the last several years, the role of vitamin D in immunomodulation has been studied and shown to have a significant impact on immune function. A causal relationship exists between vitamin D function and innate and adaptive immunity to infections. The mechanisms underlying vitamin D immune actions could be attributed to a paracrine feedback loop that reduces inflammation as well as influencing the differentiation fate of activated CD4 T cells, or the enhancement of suppressor T-cell function; indeed, a combination of these factors may underlie the actions of vitamin D. Summary: Recent findings on the function of vitamin D may explain aspects of the pathophysiology of allergic rhinitis and CRS and may help direct future interventions and treatment of these diseases.
Original language | English (US) |
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Pages (from-to) | 224-228 |
Number of pages | 5 |
Journal | Current Opinion in Otolaryngology and Head and Neck Surgery |
Volume | 19 |
Issue number | 3 |
DOIs | |
State | Published - Jun 2011 |
Externally published | Yes |
Keywords
- allergic rhinitis
- asthma
- chronic rhinosinusitis
- immunomodulation
- vitamin D
ASJC Scopus subject areas
- Surgery
- Otorhinolaryngology