Vitamin D: Immunomodulation of asthma, allergic rhinitis, and chronic rhinosinusitis

Nadeem A. Akbar, Mark A. Zacharek

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Purpose of review: To discuss the role of vitamin D in asthma, allergic rhinitis, and chronic rhinosinusitis (CRS). Recent findings: Over the last several years, the role of vitamin D in immunomodulation has been studied and shown to have a significant impact on immune function. A causal relationship exists between vitamin D function and innate and adaptive immunity to infections. The mechanisms underlying vitamin D immune actions could be attributed to a paracrine feedback loop that reduces inflammation as well as influencing the differentiation fate of activated CD4 T cells, or the enhancement of suppressor T-cell function; indeed, a combination of these factors may underlie the actions of vitamin D. Summary: Recent findings on the function of vitamin D may explain aspects of the pathophysiology of allergic rhinitis and CRS and may help direct future interventions and treatment of these diseases.

Original languageEnglish (US)
Pages (from-to)224-228
Number of pages5
JournalCurrent Opinion in Otolaryngology and Head and Neck Surgery
Volume19
Issue number3
DOIs
StatePublished - Jun 1 2011
Externally publishedYes

Keywords

  • allergic rhinitis
  • asthma
  • chronic rhinosinusitis
  • immunomodulation
  • vitamin D

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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