Vitamin D control of gene expression: Temporal and spatial parameters for organization of the regulatory machinery

Martin Montecino, Gary S. Stein, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Loreto Carvallo, Sylvain Marcellini, Fernando Cruzat, Gloria Arriagada

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Vitamin D is a principal modulator of skeletal gene expression, thus necessitating an understanding of interfaces between the activity of this steroid hormone and regulatory cascades that are functionally linked to the regulation of skeletal genes. Physiologic responsiveness requires combinatorial control, whereas coregulatory proteins determine the specificity of biologic responsiveness to physiologic cues. It is becoming increasingly evident that regulatory complexes containing the vitamin D receptor are dynamic rather than static. Temporal and spatial modifications in the composition of these complexes provide a mechanism for integrating regulatory signals to support positive or negative control through synergism and antagonism. Compartmentalization of components of vitamin D control in nuclear microenvironments supports the integration of regulatory activities, perhaps by establishing thresholds for protein activity in time frames that are consistent with the execution of regulatory signaling.

Original languageEnglish (US)
Pages (from-to)163-172
Number of pages10
JournalCritical Reviews in Eukaryotic Gene Expression
Volume18
Issue number2
DOIs
StatePublished - 2008

Keywords

  • Chromatin
  • Osteoblasts
  • Transcription
  • Vitamin D receptor

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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    Montecino, M., Stein, G. S., Stein, J. L., Lian, J. B., Van Wijnen, A. J., Carvallo, L., Marcellini, S., Cruzat, F., & Arriagada, G. (2008). Vitamin D control of gene expression: Temporal and spatial parameters for organization of the regulatory machinery. Critical Reviews in Eukaryotic Gene Expression, 18(2), 163-172. https://doi.org/10.1615/CritRevEukarGeneExpr.v18.i2.50