Vitamin D and type 2 diabetes mellitus

S. Cangoz, Y. Y. Chang, S. J. Chempakaseril, R. C. Guduru, L. M. Huynh, J. S. John, S. T. John, M. E. Joseph, R. Judge, R. Kimmey, K. Kudratov, P. J. Lee, I. C. Madhani, P. J. Shim, S. Singh, S. Singh, C. Ruchalski, R. B. Raffa

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Summary What is known and Objective The deleterious effect of vitamin D deficiency on bone health has long been known. More recent studies suggest a deleterious effect of low vitamin D (hypovitaminosis D) on general health. And specific studies propose an association between hypovitaminosis D and the aetiology and progression of type 2 diabetes (T2DM). Given a commonly assumed lack of toxicity of vitamin D, routine measurement of plasma vitamin D and supplementation is rapidly becoming accepted general practice. Comment Authoritative practice guidelines have raised the level of vitamin D that is to be considered minimal for optimum health. This recommendation was based on a wealth of information and definitive evidence for skeletal benefits of vitamin D, but there was a lack of compelling evidence that hypovitaminosis D is causally related to extra-skeletal health outcomes such as diabetes. Hence, vitamin D supplementation for the purpose of achieving a level consistent with good health is evidence based, but measurement and supplementation for the purpose of preventing or treating T2DM is not. What is new and Conclusion Although the maintenance of adequate vitamin D levels is desirable for all patients, we conclude that routine measurement of vitamin D level in every patient or initiating high-dose supplementation for the purpose of preventing or treating T2DM is not evidence based.

Original languageEnglish (US)
Pages (from-to)81-84
Number of pages4
JournalJournal of Clinical Pharmacy and Therapeutics
Volume38
Issue number2
DOIs
StatePublished - Apr 2013
Externally publishedYes

Fingerprint

Ergocalciferols
Vitamin D
Type 2 Diabetes Mellitus
Health
Vitamin D Deficiency
Practice Guidelines
General Practice
Bone and Bones

Keywords

  • 25-hydroxyvitamin D
  • diabetes
  • evidence-based medicine
  • hypovitaminosis
  • vitamin D

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Cangoz, S., Chang, Y. Y., Chempakaseril, S. J., Guduru, R. C., Huynh, L. M., John, J. S., ... Raffa, R. B. (2013). Vitamin D and type 2 diabetes mellitus. Journal of Clinical Pharmacy and Therapeutics, 38(2), 81-84. https://doi.org/10.1111/jcpt.12026

Vitamin D and type 2 diabetes mellitus. / Cangoz, S.; Chang, Y. Y.; Chempakaseril, S. J.; Guduru, R. C.; Huynh, L. M.; John, J. S.; John, S. T.; Joseph, M. E.; Judge, R.; Kimmey, R.; Kudratov, K.; Lee, P. J.; Madhani, I. C.; Shim, P. J.; Singh, S.; Singh, S.; Ruchalski, C.; Raffa, R. B.

In: Journal of Clinical Pharmacy and Therapeutics, Vol. 38, No. 2, 04.2013, p. 81-84.

Research output: Contribution to journalReview article

Cangoz, S, Chang, YY, Chempakaseril, SJ, Guduru, RC, Huynh, LM, John, JS, John, ST, Joseph, ME, Judge, R, Kimmey, R, Kudratov, K, Lee, PJ, Madhani, IC, Shim, PJ, Singh, S, Singh, S, Ruchalski, C & Raffa, RB 2013, 'Vitamin D and type 2 diabetes mellitus', Journal of Clinical Pharmacy and Therapeutics, vol. 38, no. 2, pp. 81-84. https://doi.org/10.1111/jcpt.12026
Cangoz S, Chang YY, Chempakaseril SJ, Guduru RC, Huynh LM, John JS et al. Vitamin D and type 2 diabetes mellitus. Journal of Clinical Pharmacy and Therapeutics. 2013 Apr;38(2):81-84. https://doi.org/10.1111/jcpt.12026
Cangoz, S. ; Chang, Y. Y. ; Chempakaseril, S. J. ; Guduru, R. C. ; Huynh, L. M. ; John, J. S. ; John, S. T. ; Joseph, M. E. ; Judge, R. ; Kimmey, R. ; Kudratov, K. ; Lee, P. J. ; Madhani, I. C. ; Shim, P. J. ; Singh, S. ; Singh, S. ; Ruchalski, C. ; Raffa, R. B. / Vitamin D and type 2 diabetes mellitus. In: Journal of Clinical Pharmacy and Therapeutics. 2013 ; Vol. 38, No. 2. pp. 81-84.
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N2 - Summary What is known and Objective The deleterious effect of vitamin D deficiency on bone health has long been known. More recent studies suggest a deleterious effect of low vitamin D (hypovitaminosis D) on general health. And specific studies propose an association between hypovitaminosis D and the aetiology and progression of type 2 diabetes (T2DM). Given a commonly assumed lack of toxicity of vitamin D, routine measurement of plasma vitamin D and supplementation is rapidly becoming accepted general practice. Comment Authoritative practice guidelines have raised the level of vitamin D that is to be considered minimal for optimum health. This recommendation was based on a wealth of information and definitive evidence for skeletal benefits of vitamin D, but there was a lack of compelling evidence that hypovitaminosis D is causally related to extra-skeletal health outcomes such as diabetes. Hence, vitamin D supplementation for the purpose of achieving a level consistent with good health is evidence based, but measurement and supplementation for the purpose of preventing or treating T2DM is not. What is new and Conclusion Although the maintenance of adequate vitamin D levels is desirable for all patients, we conclude that routine measurement of vitamin D level in every patient or initiating high-dose supplementation for the purpose of preventing or treating T2DM is not evidence based.

AB - Summary What is known and Objective The deleterious effect of vitamin D deficiency on bone health has long been known. More recent studies suggest a deleterious effect of low vitamin D (hypovitaminosis D) on general health. And specific studies propose an association between hypovitaminosis D and the aetiology and progression of type 2 diabetes (T2DM). Given a commonly assumed lack of toxicity of vitamin D, routine measurement of plasma vitamin D and supplementation is rapidly becoming accepted general practice. Comment Authoritative practice guidelines have raised the level of vitamin D that is to be considered minimal for optimum health. This recommendation was based on a wealth of information and definitive evidence for skeletal benefits of vitamin D, but there was a lack of compelling evidence that hypovitaminosis D is causally related to extra-skeletal health outcomes such as diabetes. Hence, vitamin D supplementation for the purpose of achieving a level consistent with good health is evidence based, but measurement and supplementation for the purpose of preventing or treating T2DM is not. What is new and Conclusion Although the maintenance of adequate vitamin D levels is desirable for all patients, we conclude that routine measurement of vitamin D level in every patient or initiating high-dose supplementation for the purpose of preventing or treating T2DM is not evidence based.

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