Vitamin D and cardiovascular disease

Not too little and not too much? The need for clinical trials

Michal L. Melamed, Jo Ann E Manson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Recent attention in observational studies has focused primarily on low vitamin D as a risk factor for multiple chronic health conditions. These conditions include but are not limited to insulin resistance, high blood pressure, cardiovascular disease, specific cancers, and early mortality. However, results from randomized clinical trials in this area have been inconsistent. Animal studies show that vitamin D is an inhibitor of the reninangiotensin system but also that high dose vitamin D in combination with a high cholesterol diet leads to atherosclerosis. There has been little focus on potential harmful effects of high vitamin D levels including the risk of vascular calcification, hypercalcemia, and kidney stones. In this review we will detail the findings from observational studies and randomized clinical trials about potential cardiovascular risks of low vitamin D levels and potential harms of very high levels. We will also summarize on-going clinical trials evaluating whether vitamin D supplementation can protect against cardiovascular and other diseases.

Original languageEnglish (US)
Title of host publicationVitamin D: Nutrition, Side Effects and Supplements
PublisherNova Science Publishers, Inc.
Pages183-192
Number of pages10
ISBN (Print)9781617286018
StatePublished - 2011

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Vitamin D
Cardiovascular Diseases
Clinical Trials
Observational Studies
Randomized Controlled Trials
Vascular Calcification
Kidney Calculi
Hypercalcemia
Insulin Resistance
Atherosclerosis
Cholesterol
Diet
Hypertension
Mortality
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Melamed, M. L., & Manson, J. A. E. (2011). Vitamin D and cardiovascular disease: Not too little and not too much? The need for clinical trials. In Vitamin D: Nutrition, Side Effects and Supplements (pp. 183-192). Nova Science Publishers, Inc..

Vitamin D and cardiovascular disease : Not too little and not too much? The need for clinical trials. / Melamed, Michal L.; Manson, Jo Ann E.

Vitamin D: Nutrition, Side Effects and Supplements. Nova Science Publishers, Inc., 2011. p. 183-192.

Research output: Chapter in Book/Report/Conference proceedingChapter

Melamed, ML & Manson, JAE 2011, Vitamin D and cardiovascular disease: Not too little and not too much? The need for clinical trials. in Vitamin D: Nutrition, Side Effects and Supplements. Nova Science Publishers, Inc., pp. 183-192.
Melamed ML, Manson JAE. Vitamin D and cardiovascular disease: Not too little and not too much? The need for clinical trials. In Vitamin D: Nutrition, Side Effects and Supplements. Nova Science Publishers, Inc. 2011. p. 183-192
Melamed, Michal L. ; Manson, Jo Ann E. / Vitamin D and cardiovascular disease : Not too little and not too much? The need for clinical trials. Vitamin D: Nutrition, Side Effects and Supplements. Nova Science Publishers, Inc., 2011. pp. 183-192
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