Vitamin D and cardiovascular disease and cancer: Not too much and not too little? The need for clinical trials

Michal L. Melamed, Jo Ann E. Manson

Research output: Contribution to journalReview article

7 Scopus citations


Low vitamin D levels are more common in women than in men. Low vitamin D levels have been implicated in numerous disease processes including fracture risk, falls, cardiovascular disease, hypertension, diabetes mellitus and cancers. In this article we review recent evidence regarding associations between low vitamin D levels and cancers and cardiovascular disease. We also review evidence regarding associations between high vitamin D levels and vascular calcifications and pancreatic cancer. It appears that there is probably an optimal level of vitamin D that is neither too high nor too low that is required to maximize health. On going clinical trials should aid in elucidating the optimal levels of 25-hydroxyvitamin D for numerous health outcomes.

Original languageEnglish (US)
Pages (from-to)419-424
Number of pages6
JournalWomen's Health
Issue number4
StatePublished - Jul 1 2011



  • 25-hydroxyvitamin D
  • cancer
  • cardiovascular disease
  • diabetes mellitus
  • hypertension
  • pancreatic cancer
  • vitamin D

ASJC Scopus subject areas

  • Medicine(all)

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