Vitamin D and Cardiovascular Disease

Kaushal Sondarwa, Rupinder S. Buttar, Victoria Hensley, Michal L. Melamed

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Low vitamin D levels are associated with cardiovascular disease and its precursors, hypertension, and diabetes mellitus. In this chapter, we review mechanistic studies in animals and tissue culture which suggest the role of vitamin D in controlling the renin-angiotensin-aldosterone system. Multiple observational studies in humans have shown an association between low vitamin D levels and cardiovascular disease and hypertension and diabetes mellitus. Mendelian randomization studies and randomized clinical trials have shown mixed results. Current ongoing clinical trials will clarify whether the vitamin D and cardiovascular disease connection is a causal one.

Original languageEnglish (US)
Title of host publicationContemporary Endocrinology
PublisherHumana Press Inc.
Pages151-164
Number of pages14
DOIs
StatePublished - Jan 1 2018

Publication series

NameContemporary Endocrinology
ISSN (Print)2523-3785
ISSN (Electronic)2523-3793

Keywords

  • Cardiovascular disease
  • Diabetes mellitus
  • Hypertension
  • Myocardial infarction
  • Vitamin D

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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