Vitamin D and Cardiovascular Disease

Kaushal Sondarwa, Rupinder S. Buttar, Victoria Hensley, Michal L. Melamed

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Low vitamin D levels are associated with cardiovascular disease and its precursors, hypertension, and diabetes mellitus. In this chapter, we review mechanistic studies in animals and tissue culture which suggest the role of vitamin D in controlling the renin-angiotensin-aldosterone system. Multiple observational studies in humans have shown an association between low vitamin D levels and cardiovascular disease and hypertension and diabetes mellitus. Mendelian randomization studies and randomized clinical trials have shown mixed results. Current ongoing clinical trials will clarify whether the vitamin D and cardiovascular disease connection is a causal one.

Original languageEnglish (US)
Title of host publicationContemporary Endocrinology
PublisherHumana Press Inc.
Pages151-164
Number of pages14
DOIs
StatePublished - Jan 1 2018

Publication series

NameContemporary Endocrinology
ISSN (Print)2523-3785
ISSN (Electronic)2523-3793

Fingerprint

Vitamin D
Cardiovascular Diseases
Diabetes Mellitus
Hypertension
Renin-Angiotensin System
Random Allocation
Observational Studies
Randomized Controlled Trials
Clinical Trials

Keywords

  • Cardiovascular disease
  • Diabetes mellitus
  • Hypertension
  • Myocardial infarction
  • Vitamin D

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Sondarwa, K., Buttar, R. S., Hensley, V., & Melamed, M. L. (2018). Vitamin D and Cardiovascular Disease. In Contemporary Endocrinology (pp. 151-164). (Contemporary Endocrinology). Humana Press Inc.. https://doi.org/10.1007/978-3-319-73742-3_8

Vitamin D and Cardiovascular Disease. / Sondarwa, Kaushal; Buttar, Rupinder S.; Hensley, Victoria; Melamed, Michal L.

Contemporary Endocrinology. Humana Press Inc., 2018. p. 151-164 (Contemporary Endocrinology).

Research output: Chapter in Book/Report/Conference proceedingChapter

Sondarwa, K, Buttar, RS, Hensley, V & Melamed, ML 2018, Vitamin D and Cardiovascular Disease. in Contemporary Endocrinology. Contemporary Endocrinology, Humana Press Inc., pp. 151-164. https://doi.org/10.1007/978-3-319-73742-3_8
Sondarwa K, Buttar RS, Hensley V, Melamed ML. Vitamin D and Cardiovascular Disease. In Contemporary Endocrinology. Humana Press Inc. 2018. p. 151-164. (Contemporary Endocrinology). https://doi.org/10.1007/978-3-319-73742-3_8
Sondarwa, Kaushal ; Buttar, Rupinder S. ; Hensley, Victoria ; Melamed, Michal L. / Vitamin D and Cardiovascular Disease. Contemporary Endocrinology. Humana Press Inc., 2018. pp. 151-164 (Contemporary Endocrinology).
@inbook{a3f634d73ae7455d915ab052e919db02,
title = "Vitamin D and Cardiovascular Disease",
abstract = "Low vitamin D levels are associated with cardiovascular disease and its precursors, hypertension, and diabetes mellitus. In this chapter, we review mechanistic studies in animals and tissue culture which suggest the role of vitamin D in controlling the renin-angiotensin-aldosterone system. Multiple observational studies in humans have shown an association between low vitamin D levels and cardiovascular disease and hypertension and diabetes mellitus. Mendelian randomization studies and randomized clinical trials have shown mixed results. Current ongoing clinical trials will clarify whether the vitamin D and cardiovascular disease connection is a causal one.",
keywords = "Cardiovascular disease, Diabetes mellitus, Hypertension, Myocardial infarction, Vitamin D",
author = "Kaushal Sondarwa and Buttar, {Rupinder S.} and Victoria Hensley and Melamed, {Michal L.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1007/978-3-319-73742-3_8",
language = "English (US)",
series = "Contemporary Endocrinology",
publisher = "Humana Press Inc.",
pages = "151--164",
booktitle = "Contemporary Endocrinology",

}

TY - CHAP

T1 - Vitamin D and Cardiovascular Disease

AU - Sondarwa, Kaushal

AU - Buttar, Rupinder S.

AU - Hensley, Victoria

AU - Melamed, Michal L.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Low vitamin D levels are associated with cardiovascular disease and its precursors, hypertension, and diabetes mellitus. In this chapter, we review mechanistic studies in animals and tissue culture which suggest the role of vitamin D in controlling the renin-angiotensin-aldosterone system. Multiple observational studies in humans have shown an association between low vitamin D levels and cardiovascular disease and hypertension and diabetes mellitus. Mendelian randomization studies and randomized clinical trials have shown mixed results. Current ongoing clinical trials will clarify whether the vitamin D and cardiovascular disease connection is a causal one.

AB - Low vitamin D levels are associated with cardiovascular disease and its precursors, hypertension, and diabetes mellitus. In this chapter, we review mechanistic studies in animals and tissue culture which suggest the role of vitamin D in controlling the renin-angiotensin-aldosterone system. Multiple observational studies in humans have shown an association between low vitamin D levels and cardiovascular disease and hypertension and diabetes mellitus. Mendelian randomization studies and randomized clinical trials have shown mixed results. Current ongoing clinical trials will clarify whether the vitamin D and cardiovascular disease connection is a causal one.

KW - Cardiovascular disease

KW - Diabetes mellitus

KW - Hypertension

KW - Myocardial infarction

KW - Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=85064863011&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064863011&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-73742-3_8

DO - 10.1007/978-3-319-73742-3_8

M3 - Chapter

AN - SCOPUS:85064863011

T3 - Contemporary Endocrinology

SP - 151

EP - 164

BT - Contemporary Endocrinology

PB - Humana Press Inc.

ER -