Vitamin C levels amongst initial survivors of out of hospital cardiac arrest

Ryan Gardner, Xiaowen Liu, Yanbo Wang, Andrew Cole, Stanley Heydrick, Michael W. Donnino, Ari Moskowitz

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Vitamin C deficiency has been described in patients with sepsis. The post-cardiac arrest syndrome shares similarities to sepsis, however vitamin C levels in post-arrest patients have been incompletely characterized. We assessed vitamin C levels in a post-arrest population. Methods: This was a retrospective observational study at a tertiary care center. A convenience sample of post-arrest, sepsis, and healthy control patients was selected from prior studies. Vitamin C levels were measured from samples obtained within 6-h of emergency department admission. A subset of cardiac arrest patients had vitamin C levels additionally measured 24-h later. Results: A total of 84 patients (34 healthy controls, 25 post-arrest, and 25 septic patients) were included. The median baseline vitamin C level in cardiac arrest patients was 0.33 mg/dL (0.05–0.83), as compared to 0.91 mg/dL (0.69–1.48) in the healthy control group (p < 0.01) and 0.28 mg/dL (0.11–0.59) in the septic group (p = 0.36). Vitamin C levels for cardiac arrest patients fell between the two time points, but the change was not statistically significant (median decrease 0.26 mg/dL, p = 0.08). Conclusions: Serum vitamin C levels were lower in post-arrest patients compared to controls and were similar to patients with sepsis. Future studies of vitamin C levels and supplementation following cardiac arrest may be warranted.

Original languageEnglish (US)
Pages (from-to)190-193
Number of pages4
JournalResuscitation
Volume156
DOIs
StatePublished - Nov 2020
Externally publishedYes

Keywords

  • Ascorbic acid
  • Cardiac arrest
  • Out of hospital
  • Post-cardiac arrest
  • Sepsis
  • Vitamin C

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency
  • Cardiology and Cardiovascular Medicine

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