Visualizing the Histone Code on LSD1

Matthew J. Gamble, W. Lee Kraus

Research output: Contribution to journalShort survey

5 Scopus citations

Abstract

In this issue, Garcia-Bassets et al. (2007) show that spurious transcriptional activation by unliganded nuclear receptors is inhibited by histone lysine methylation. This inhibitory histone modification code is efficiently countered by the ligand-dependent recruitment of histone lysine demethylases, including lysine-specific demethylase 1 (LSD1), which appear to be used for this purpose by a number of signal-regulated transcriptional activators.

Original languageEnglish (US)
Pages (from-to)433-434
Number of pages2
JournalCell
Volume128
Issue number3
DOIs
StatePublished - Feb 9 2007

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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