Visceral adipose tissue modulates mammalian longevity

Radhika Muzumdar, David B. Allison, Derek M. Huffman, Xiaohui Ma, Gil Atzmon, Francine H. Einstein, Sigal Fishman, Aruna D. Poduval, Theresa McVei, Scott W. Keith, Nir Barzilai

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

Caloric restriction (CR) can delay many age-related diseases and extend lifespan, while an increase in adiposity is associated with enhanced disease risk and accelerated aging. Among the various fat depots, the accrual of visceral fat (VF) is a common feature of aging, and has been shown to be the most detrimental on metabolic syndrome of aging in humans. We have previously demonstrated that surgical removal of VF in rats improves insulin action; thus, we set out to determine if VF removal affects longevity. We prospectively studied lifespan in three groups of rats: ad libitum-fed (AL-fed), CR (Fed 60% of AL) and a group of AL-fed rats with selective removal of VF at 5 months of age (VF-removed rats). We demonstrate that compared to AL-fed rats, VF-removed rats had a significant increase in mean (p < 0.001) and maximum lifespan (p < 0.04) and significant reduction in the incidence of severe renal disease (p < 0.01). CR rats demonstrated the greatest mean and maximum lifespan (p < 0.001) and the lowest rate of death as compared to AL-fed rats (0.13). Taken together, these observations provide the most direct evidence to date that a reduction in fat mass, specifically VF, may be one of the possible underlying mechanisms of the anti-aging effect of CR.

Original languageEnglish (US)
Pages (from-to)438-440
Number of pages3
JournalAging Cell
Volume7
Issue number3
DOIs
StatePublished - Jun 2008

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Intra-Abdominal Fat
Caloric Restriction
Fats
Adiposity
Insulin
Kidney
Mortality
Incidence

Keywords

  • Aging
  • Caloric restriction
  • Life span
  • Obesity
  • Visceral fat removal

ASJC Scopus subject areas

  • Cell Biology

Cite this

Visceral adipose tissue modulates mammalian longevity. / Muzumdar, Radhika; Allison, David B.; Huffman, Derek M.; Ma, Xiaohui; Atzmon, Gil; Einstein, Francine H.; Fishman, Sigal; Poduval, Aruna D.; McVei, Theresa; Keith, Scott W.; Barzilai, Nir.

In: Aging Cell, Vol. 7, No. 3, 06.2008, p. 438-440.

Research output: Contribution to journalArticle

Muzumdar, R, Allison, DB, Huffman, DM, Ma, X, Atzmon, G, Einstein, FH, Fishman, S, Poduval, AD, McVei, T, Keith, SW & Barzilai, N 2008, 'Visceral adipose tissue modulates mammalian longevity', Aging Cell, vol. 7, no. 3, pp. 438-440. https://doi.org/10.1111/j.1474-9726.2008.00391.x
Muzumdar R, Allison DB, Huffman DM, Ma X, Atzmon G, Einstein FH et al. Visceral adipose tissue modulates mammalian longevity. Aging Cell. 2008 Jun;7(3):438-440. https://doi.org/10.1111/j.1474-9726.2008.00391.x
Muzumdar, Radhika ; Allison, David B. ; Huffman, Derek M. ; Ma, Xiaohui ; Atzmon, Gil ; Einstein, Francine H. ; Fishman, Sigal ; Poduval, Aruna D. ; McVei, Theresa ; Keith, Scott W. ; Barzilai, Nir. / Visceral adipose tissue modulates mammalian longevity. In: Aging Cell. 2008 ; Vol. 7, No. 3. pp. 438-440.
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