Virulence of Mycobacterium tuberculosis CDC1551 and H37Rv in rabbits evaluated by Lurie's pulmonary tubercle count method

William R. Bishai, Arthur M. Dannenberg, Nikki Parrish, Rafael Ruiz, Ping Chen, Bernard C. Zook, Walter Johnson, James W. Boles, M. Louise M. Pitt

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

The virulence of the CDC1551 strain of Mycobacterium tuberculosis was compared to that of H37Rv in a rabbit inhalation model. While rabbits that inhaled the two strains produced equal numbers of grossly visible primary tubercles, CDC1551 tubercles were smaller and contained fewer bacilli than H37Rv tubercles. These findings suggest that a miniepidemic near the Kentucky-Tennessee border caused by CDC1551 was due not to increased virulence but to increased transmissibility.

Original languageEnglish (US)
Pages (from-to)4931-4934
Number of pages4
JournalInfection and immunity
Volume67
Issue number9
DOIs
StatePublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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    Bishai, W. R., Dannenberg, A. M., Parrish, N., Ruiz, R., Chen, P., Zook, B. C., Johnson, W., Boles, J. W., & Pitt, M. L. M. (1999). Virulence of Mycobacterium tuberculosis CDC1551 and H37Rv in rabbits evaluated by Lurie's pulmonary tubercle count method. Infection and immunity, 67(9), 4931-4934. https://doi.org/10.1128/iai.67.9.4931-4934.1999