Viral load of human papillomavirus and risk of CIN3 or cervical cancer

Attila T. Lorincz; Philip E. Castle; Mark E. Sherman; David R. Scott; Andrew G. Glass; Sholom Wacholder; Brenda B. Rush; Patti E. Gravitt; John E. Schussler; Mark Schiffman

doi:10.1016/S0140-6736(02)09463-1

Viral load of human papillomavirus and risk of CIN3 or cervical cancer

Attila T. Lorincz, Philip E. Castle, Mark E. Sherman, David R. Scott, Andrew G. Glass, Sholom Wacholder, Brenda B. Rush, Patti E. Gravitt, John E. Schussler, Mark Schiffman

Research output: Contribution to journal › Article › peer-review

209 Scopus citations

Abstract

Carcinogenic human papillomaviruses (HPV) are thought to be necessary for development of cervical cancer. We assessed whether higher viral loads of such viruses predicted future risk of CIN3 or cancer (CIN3+) in a cohort of 20 810 women followed up for 10 years with cytological screening. We measured the viral load for 13 types of carcinogenic HPV (relative light units normalised to 1 pg/mL HPV 16 positive controls [RLU/PC]) using Hybrid Capture 2 testing of cervicovaginal lavages obtained at enrolment. Results were stratified into four groups (RLU/PC 1 to <10, 10 to <100, 100 to <1000, ≥1000). Although presence of HPV strongly increased risk of CIN3+, high viral load did not further predict risk of CIN3+.

Original language	English (US)
Pages (from-to)	228-229
Number of pages	2
Journal	Lancet
Volume	360
Issue number	9328
DOIs	https://doi.org/10.1016/S0140-6736(02)09463-1
State	Published - Jul 20 2002
Externally published	Yes

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0140-6736(02)09463-1

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@article{74d95c1bda134379b4ce614a3dee98a5,

title = "Viral load of human papillomavirus and risk of CIN3 or cervical cancer",

abstract = "Carcinogenic human papillomaviruses (HPV) are thought to be necessary for development of cervical cancer. We assessed whether higher viral loads of such viruses predicted future risk of CIN3 or cancer (CIN3+) in a cohort of 20 810 women followed up for 10 years with cytological screening. We measured the viral load for 13 types of carcinogenic HPV (relative light units normalised to 1 pg/mL HPV 16 positive controls [RLU/PC]) using Hybrid Capture 2 testing of cervicovaginal lavages obtained at enrolment. Results were stratified into four groups (RLU/PC 1 to <10, 10 to <100, 100 to <1000, ≥1000). Although presence of HPV strongly increased risk of CIN3+, high viral load did not further predict risk of CIN3+.",

author = "Lorincz, {Attila T.} and Castle, {Philip E.} and Sherman, {Mark E.} and Scott, {David R.} and Glass, {Andrew G.} and Sholom Wacholder and Rush, {Brenda B.} and Gravitt, {Patti E.} and Schussler, {John E.} and Mark Schiffman",

note = "Funding Information: This study was funded intramurally by the National Cancer Institute. HPV testing was done masked at Digene Corporation, which also provided the HPV kits and labour necessary to do this testing. J Buckland of Information Management Services assisted with the management and statistical analysis.",

year = "2002",

month = jul,

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doi = "10.1016/S0140-6736(02)09463-1",

language = "English (US)",

volume = "360",

pages = "228--229",

journal = "Lancet",

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T1 - Viral load of human papillomavirus and risk of CIN3 or cervical cancer

AU - Lorincz, Attila T.

AU - Castle, Philip E.

AU - Sherman, Mark E.

AU - Scott, David R.

AU - Glass, Andrew G.

AU - Wacholder, Sholom

AU - Rush, Brenda B.

AU - Gravitt, Patti E.

AU - Schussler, John E.

AU - Schiffman, Mark

N1 - Funding Information: This study was funded intramurally by the National Cancer Institute. HPV testing was done masked at Digene Corporation, which also provided the HPV kits and labour necessary to do this testing. J Buckland of Information Management Services assisted with the management and statistical analysis.

PY - 2002/7/20

Y1 - 2002/7/20

N2 - Carcinogenic human papillomaviruses (HPV) are thought to be necessary for development of cervical cancer. We assessed whether higher viral loads of such viruses predicted future risk of CIN3 or cancer (CIN3+) in a cohort of 20 810 women followed up for 10 years with cytological screening. We measured the viral load for 13 types of carcinogenic HPV (relative light units normalised to 1 pg/mL HPV 16 positive controls [RLU/PC]) using Hybrid Capture 2 testing of cervicovaginal lavages obtained at enrolment. Results were stratified into four groups (RLU/PC 1 to <10, 10 to <100, 100 to <1000, ≥1000). Although presence of HPV strongly increased risk of CIN3+, high viral load did not further predict risk of CIN3+.

AB - Carcinogenic human papillomaviruses (HPV) are thought to be necessary for development of cervical cancer. We assessed whether higher viral loads of such viruses predicted future risk of CIN3 or cancer (CIN3+) in a cohort of 20 810 women followed up for 10 years with cytological screening. We measured the viral load for 13 types of carcinogenic HPV (relative light units normalised to 1 pg/mL HPV 16 positive controls [RLU/PC]) using Hybrid Capture 2 testing of cervicovaginal lavages obtained at enrolment. Results were stratified into four groups (RLU/PC 1 to <10, 10 to <100, 100 to <1000, ≥1000). Although presence of HPV strongly increased risk of CIN3+, high viral load did not further predict risk of CIN3+.

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AN - SCOPUS:0037143017

SN - 0140-6736

VL - 360

SP - 228

EP - 229

JO - Lancet

JF - Lancet

IS - 9328

ER -

Viral load of human papillomavirus and risk of CIN3 or cervical cancer

Abstract

ASJC Scopus subject areas

UN SDGs

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