Vinorelbine (Navelbine®) in the treatment of non-small-cell lung cancer: Recent developments in combination chemotherapy and radiotherapy

R. Gralla, P. Harper, S. Johnson, F. M. Delgado

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The investigation of the activity of vinorelbine in non-small-cell lung cancer (NSCLC) has continued beyond the initial studies which established its single agent activity and defined the combination of vinorelbine and cisplatin as one of the standard treatments for inoperable NSCLC. Alternative partners to cisplatin have been evaluated in combination therapy with vinorelbine with promising results emerging from combinations with carboplatin, ifosfamide, mitomycin C and gemcitabine. Three drug combinations such as vinorelbine, cisplatin and ifosfamide can clearly produce high response rates in patients with good performance status at the time of treatment. The ability of vinorelbine to contribute to disease reduction either alone or in combination with other cytotoxic drugs has made it possible to consider its use in neo-adjuvant therapy, while the synergistic action of vinorelbine with radiotherapy has encouraged the use of sequential or concomitant chemoradiotherapy producing high response rates after completion of both modalities. The possible role of post-operative adjuvant treatment with Vinorelbine either alone or in combination with cisplatin is being assessed in a prospective trial.

Original languageEnglish (US)
Pages (from-to)S47-S51
JournalAnnals of Oncology
Volume10
Issue numberSUPPL. 5
DOIs
StatePublished - Jan 1 1999

Keywords

  • Cisplatin non-small-cell lung cancer
  • Neo- adjuvant
  • Radiotherapy
  • Vinorelbine

ASJC Scopus subject areas

  • Hematology
  • Oncology

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