Vigabatrin as initial therapy for infantile spasms: A European retrospective survey

J. Aicardi, J. P. Mumford, C. Dumas, S. Wood, E. Hauser, H. Steinböck, M. Szyper, V. Holsteen, J. Ostergaard, S. A. Pedersen, K. Taudorf, M. A. Barthez-Carpentier, N. Badinand-Hubert, P. Berquin, J. Boulloche, M. Bourgeois, J. P. Carriere, B. Chabrol, C. Chiron, O. ClarisB. Echenne, D. Gauthier-Morel, M. O. Livet, N. Lopez, J. Mancini, J. C. Netter, D. Quillerou, C. H. Richelme, C. Rousselle, A. De Saint Martin, M. De Swarte, G. Auerswald, U. Brandl, G. Kurlemann, H. Siemes, H. L. Spohr, W. F M Aarts, J. H. Begeer, D. J. Heersma, L. A E M Laan, A. C B Peters, G. B. Cavazzutti, P. Curatolo, A. Fois, E. Franzoni, G. Gobbi, G. Incorpora, F. Vigevano, J. Campistol, J. Campos, C. Casas, J. L. Herranz, M. Nieto, J. M. Prats, P. Amark, G. Blennow, K. Theorell, B. Tonnby, C. A. Haenggeli, M. Weissert, R. Appleton, R. Robinson, C. De Sousa, N. Thomas, F. Andermann, R. Appleton, S. Boyd, W. Brandi, D. Buti, O. Dulac, K. Farrell, Solomon L. Moshe, J. Motte, P. Plouin, W. D. Shields

Research output: Contribution to journalArticle

175 Citations (Scopus)

Abstract

Purpose: The efficacy and tolerability of vigabatrin (VGB) as an add-on therapy in the treatment of infantile spasm (IS) prompted physicians to explore its use as the first drug in this seizure type. Methods: Our retrospective study included 250 infants diagnosed with IS: the data obtained were subjected to peer-group review. Of this infant population, 192 infants were considered to have classic IS and had received VGB as their first treatment for the spasms. There was a slight preponderance of boys (57%) in this population. Mean age of IS onset was 5.8 months; 60% had typical hypsarrhythmia. Results: Initial suppression of spasms was obtained in 68% of infants with a median time to response of 4 days at an average VGB dose of 99 mg/kg/day. The best response was seen in those infants with tuberous sclerosis(96% response) and in those younger than 3 months at onset of spasms (90% response). Of these infants, 43 (22%) of 192 subsequently had other types of seizures, and a recurrence of infantile spasms occurred in 28 (21%) of 131 responders. At the end of this study, 96 of 192 infants who could be evaluated were seizure free with VGB monotherapy. Treatment appeared to be well tolerated, with only 33 (13%) infants with adverse events, of which the most common were somnolence (15 patients) and hyperkinesia (eight patients). In only two cases did adverse events require VGB withdrawal. Conclusion: This study supports the opinion that VGB may be considered an initial treatment for IS regardless of cause.

Original languageEnglish (US)
Pages (from-to)638-642
Number of pages5
JournalEpilepsia
Volume37
Issue number7
DOIs
StatePublished - 1996
Externally publishedYes

Fingerprint

Vigabatrin
Infantile Spasms
Spasm
Seizures
Therapeutics
Hyperkinesis
Peer Group
Tuberous Sclerosis
Peer Review
Surveys and Questionnaires
Population
Retrospective Studies
Physicians
Recurrence

Keywords

  • Infantile spasms
  • Monotherapy
  • Retrospective study
  • Vigabatrin

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Aicardi, J., Mumford, J. P., Dumas, C., Wood, S., Hauser, E., Steinböck, H., ... Shields, W. D. (1996). Vigabatrin as initial therapy for infantile spasms: A European retrospective survey. Epilepsia, 37(7), 638-642. https://doi.org/10.1111/j.1528-1157.1996.tb00627.x

Vigabatrin as initial therapy for infantile spasms : A European retrospective survey. / Aicardi, J.; Mumford, J. P.; Dumas, C.; Wood, S.; Hauser, E.; Steinböck, H.; Szyper, M.; Holsteen, V.; Ostergaard, J.; Pedersen, S. A.; Taudorf, K.; Barthez-Carpentier, M. A.; Badinand-Hubert, N.; Berquin, P.; Boulloche, J.; Bourgeois, M.; Carriere, J. P.; Chabrol, B.; Chiron, C.; Claris, O.; Echenne, B.; Gauthier-Morel, D.; Livet, M. O.; Lopez, N.; Mancini, J.; Netter, J. C.; Quillerou, D.; Richelme, C. H.; Rousselle, C.; De Saint Martin, A.; De Swarte, M.; Auerswald, G.; Brandl, U.; Kurlemann, G.; Siemes, H.; Spohr, H. L.; Aarts, W. F M; Begeer, J. H.; Heersma, D. J.; Laan, L. A E M; Peters, A. C B; Cavazzutti, G. B.; Curatolo, P.; Fois, A.; Franzoni, E.; Gobbi, G.; Incorpora, G.; Vigevano, F.; Campistol, J.; Campos, J.; Casas, C.; Herranz, J. L.; Nieto, M.; Prats, J. M.; Amark, P.; Blennow, G.; Theorell, K.; Tonnby, B.; Haenggeli, C. A.; Weissert, M.; Appleton, R.; Robinson, R.; De Sousa, C.; Thomas, N.; Andermann, F.; Appleton, R.; Boyd, S.; Brandi, W.; Buti, D.; Dulac, O.; Farrell, K.; Moshe, Solomon L.; Motte, J.; Plouin, P.; Shields, W. D.

In: Epilepsia, Vol. 37, No. 7, 1996, p. 638-642.

Research output: Contribution to journalArticle

Aicardi, J, Mumford, JP, Dumas, C, Wood, S, Hauser, E, Steinböck, H, Szyper, M, Holsteen, V, Ostergaard, J, Pedersen, SA, Taudorf, K, Barthez-Carpentier, MA, Badinand-Hubert, N, Berquin, P, Boulloche, J, Bourgeois, M, Carriere, JP, Chabrol, B, Chiron, C, Claris, O, Echenne, B, Gauthier-Morel, D, Livet, MO, Lopez, N, Mancini, J, Netter, JC, Quillerou, D, Richelme, CH, Rousselle, C, De Saint Martin, A, De Swarte, M, Auerswald, G, Brandl, U, Kurlemann, G, Siemes, H, Spohr, HL, Aarts, WFM, Begeer, JH, Heersma, DJ, Laan, LAEM, Peters, ACB, Cavazzutti, GB, Curatolo, P, Fois, A, Franzoni, E, Gobbi, G, Incorpora, G, Vigevano, F, Campistol, J, Campos, J, Casas, C, Herranz, JL, Nieto, M, Prats, JM, Amark, P, Blennow, G, Theorell, K, Tonnby, B, Haenggeli, CA, Weissert, M, Appleton, R, Robinson, R, De Sousa, C, Thomas, N, Andermann, F, Appleton, R, Boyd, S, Brandi, W, Buti, D, Dulac, O, Farrell, K, Moshe, SL, Motte, J, Plouin, P & Shields, WD 1996, 'Vigabatrin as initial therapy for infantile spasms: A European retrospective survey', Epilepsia, vol. 37, no. 7, pp. 638-642. https://doi.org/10.1111/j.1528-1157.1996.tb00627.x
Aicardi, J. ; Mumford, J. P. ; Dumas, C. ; Wood, S. ; Hauser, E. ; Steinböck, H. ; Szyper, M. ; Holsteen, V. ; Ostergaard, J. ; Pedersen, S. A. ; Taudorf, K. ; Barthez-Carpentier, M. A. ; Badinand-Hubert, N. ; Berquin, P. ; Boulloche, J. ; Bourgeois, M. ; Carriere, J. P. ; Chabrol, B. ; Chiron, C. ; Claris, O. ; Echenne, B. ; Gauthier-Morel, D. ; Livet, M. O. ; Lopez, N. ; Mancini, J. ; Netter, J. C. ; Quillerou, D. ; Richelme, C. H. ; Rousselle, C. ; De Saint Martin, A. ; De Swarte, M. ; Auerswald, G. ; Brandl, U. ; Kurlemann, G. ; Siemes, H. ; Spohr, H. L. ; Aarts, W. F M ; Begeer, J. H. ; Heersma, D. J. ; Laan, L. A E M ; Peters, A. C B ; Cavazzutti, G. B. ; Curatolo, P. ; Fois, A. ; Franzoni, E. ; Gobbi, G. ; Incorpora, G. ; Vigevano, F. ; Campistol, J. ; Campos, J. ; Casas, C. ; Herranz, J. L. ; Nieto, M. ; Prats, J. M. ; Amark, P. ; Blennow, G. ; Theorell, K. ; Tonnby, B. ; Haenggeli, C. A. ; Weissert, M. ; Appleton, R. ; Robinson, R. ; De Sousa, C. ; Thomas, N. ; Andermann, F. ; Appleton, R. ; Boyd, S. ; Brandi, W. ; Buti, D. ; Dulac, O. ; Farrell, K. ; Moshe, Solomon L. ; Motte, J. ; Plouin, P. ; Shields, W. D. / Vigabatrin as initial therapy for infantile spasms : A European retrospective survey. In: Epilepsia. 1996 ; Vol. 37, No. 7. pp. 638-642.
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abstract = "Purpose: The efficacy and tolerability of vigabatrin (VGB) as an add-on therapy in the treatment of infantile spasm (IS) prompted physicians to explore its use as the first drug in this seizure type. Methods: Our retrospective study included 250 infants diagnosed with IS: the data obtained were subjected to peer-group review. Of this infant population, 192 infants were considered to have classic IS and had received VGB as their first treatment for the spasms. There was a slight preponderance of boys (57{\%}) in this population. Mean age of IS onset was 5.8 months; 60{\%} had typical hypsarrhythmia. Results: Initial suppression of spasms was obtained in 68{\%} of infants with a median time to response of 4 days at an average VGB dose of 99 mg/kg/day. The best response was seen in those infants with tuberous sclerosis(96{\%} response) and in those younger than 3 months at onset of spasms (90{\%} response). Of these infants, 43 (22{\%}) of 192 subsequently had other types of seizures, and a recurrence of infantile spasms occurred in 28 (21{\%}) of 131 responders. At the end of this study, 96 of 192 infants who could be evaluated were seizure free with VGB monotherapy. Treatment appeared to be well tolerated, with only 33 (13{\%}) infants with adverse events, of which the most common were somnolence (15 patients) and hyperkinesia (eight patients). In only two cases did adverse events require VGB withdrawal. Conclusion: This study supports the opinion that VGB may be considered an initial treatment for IS regardless of cause.",
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TY - JOUR

T1 - Vigabatrin as initial therapy for infantile spasms

T2 - A European retrospective survey

AU - Aicardi, J.

AU - Mumford, J. P.

AU - Dumas, C.

AU - Wood, S.

AU - Hauser, E.

AU - Steinböck, H.

AU - Szyper, M.

AU - Holsteen, V.

AU - Ostergaard, J.

AU - Pedersen, S. A.

AU - Taudorf, K.

AU - Barthez-Carpentier, M. A.

AU - Badinand-Hubert, N.

AU - Berquin, P.

AU - Boulloche, J.

AU - Bourgeois, M.

AU - Carriere, J. P.

AU - Chabrol, B.

AU - Chiron, C.

AU - Claris, O.

AU - Echenne, B.

AU - Gauthier-Morel, D.

AU - Livet, M. O.

AU - Lopez, N.

AU - Mancini, J.

AU - Netter, J. C.

AU - Quillerou, D.

AU - Richelme, C. H.

AU - Rousselle, C.

AU - De Saint Martin, A.

AU - De Swarte, M.

AU - Auerswald, G.

AU - Brandl, U.

AU - Kurlemann, G.

AU - Siemes, H.

AU - Spohr, H. L.

AU - Aarts, W. F M

AU - Begeer, J. H.

AU - Heersma, D. J.

AU - Laan, L. A E M

AU - Peters, A. C B

AU - Cavazzutti, G. B.

AU - Curatolo, P.

AU - Fois, A.

AU - Franzoni, E.

AU - Gobbi, G.

AU - Incorpora, G.

AU - Vigevano, F.

AU - Campistol, J.

AU - Campos, J.

AU - Casas, C.

AU - Herranz, J. L.

AU - Nieto, M.

AU - Prats, J. M.

AU - Amark, P.

AU - Blennow, G.

AU - Theorell, K.

AU - Tonnby, B.

AU - Haenggeli, C. A.

AU - Weissert, M.

AU - Appleton, R.

AU - Robinson, R.

AU - De Sousa, C.

AU - Thomas, N.

AU - Andermann, F.

AU - Appleton, R.

AU - Boyd, S.

AU - Brandi, W.

AU - Buti, D.

AU - Dulac, O.

AU - Farrell, K.

AU - Moshe, Solomon L.

AU - Motte, J.

AU - Plouin, P.

AU - Shields, W. D.

PY - 1996

Y1 - 1996

N2 - Purpose: The efficacy and tolerability of vigabatrin (VGB) as an add-on therapy in the treatment of infantile spasm (IS) prompted physicians to explore its use as the first drug in this seizure type. Methods: Our retrospective study included 250 infants diagnosed with IS: the data obtained were subjected to peer-group review. Of this infant population, 192 infants were considered to have classic IS and had received VGB as their first treatment for the spasms. There was a slight preponderance of boys (57%) in this population. Mean age of IS onset was 5.8 months; 60% had typical hypsarrhythmia. Results: Initial suppression of spasms was obtained in 68% of infants with a median time to response of 4 days at an average VGB dose of 99 mg/kg/day. The best response was seen in those infants with tuberous sclerosis(96% response) and in those younger than 3 months at onset of spasms (90% response). Of these infants, 43 (22%) of 192 subsequently had other types of seizures, and a recurrence of infantile spasms occurred in 28 (21%) of 131 responders. At the end of this study, 96 of 192 infants who could be evaluated were seizure free with VGB monotherapy. Treatment appeared to be well tolerated, with only 33 (13%) infants with adverse events, of which the most common were somnolence (15 patients) and hyperkinesia (eight patients). In only two cases did adverse events require VGB withdrawal. Conclusion: This study supports the opinion that VGB may be considered an initial treatment for IS regardless of cause.

AB - Purpose: The efficacy and tolerability of vigabatrin (VGB) as an add-on therapy in the treatment of infantile spasm (IS) prompted physicians to explore its use as the first drug in this seizure type. Methods: Our retrospective study included 250 infants diagnosed with IS: the data obtained were subjected to peer-group review. Of this infant population, 192 infants were considered to have classic IS and had received VGB as their first treatment for the spasms. There was a slight preponderance of boys (57%) in this population. Mean age of IS onset was 5.8 months; 60% had typical hypsarrhythmia. Results: Initial suppression of spasms was obtained in 68% of infants with a median time to response of 4 days at an average VGB dose of 99 mg/kg/day. The best response was seen in those infants with tuberous sclerosis(96% response) and in those younger than 3 months at onset of spasms (90% response). Of these infants, 43 (22%) of 192 subsequently had other types of seizures, and a recurrence of infantile spasms occurred in 28 (21%) of 131 responders. At the end of this study, 96 of 192 infants who could be evaluated were seizure free with VGB monotherapy. Treatment appeared to be well tolerated, with only 33 (13%) infants with adverse events, of which the most common were somnolence (15 patients) and hyperkinesia (eight patients). In only two cases did adverse events require VGB withdrawal. Conclusion: This study supports the opinion that VGB may be considered an initial treatment for IS regardless of cause.

KW - Infantile spasms

KW - Monotherapy

KW - Retrospective study

KW - Vigabatrin

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