Vestibular pathology in children with enlarged vestibular aqueduct

Christina J. Yang, Violette Lavender, Jareen K. Meinzen-Derr, Aliza P. Cohen, Mostafa Youssif, Micheal Castiglione, Vairavan Manickam, Katheryn R. Bachmann, John H. Greinwald

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objectives/Hypothesis: To establish the prevalence of abnormal vestibular test findings in children with enlarged vestibular aqueduct (EVA) and determine if these findings correlate with clinical symptoms, radiographic findings (EVA size and laterality), audiometric findings, and genetic testing in these patients. Study Design: Prospective cohort. Methods: Patients 3 to 12 years of age with hearing loss and imaging findings consistent with EVA treated at our tertiary care institution were sequentially enrolled from 2009 to 2011. The following six outcome measurements were analyzed: audiometric findings, EVA laterality, temporal bone measurements, genetic testing, vestibular testing (cervical-evoked myogenic potentials, posturography, rotational chair, and calorics), and vestibular symptoms. Results: Twenty-seven patients with EVA (mean age 9.2 years, 48% female) were enrolled in and completed the study. Vertigo was reported in six patients. Twenty-four of 27 (89%) had at least one abnormal vestibular test result. Midpoint and operculum size correlated with directional preponderance (P =.042 and P =.032, respectively). Also, high-frequency pure tone average (HFPTA) correlated with unilateral weakness (P =.002). Walking at a later age correlated with abnormal posturography results. There was no correlation between EVA laterality and vestibular test findings. Conclusion: We found a high rate of vestibular pathology in children with EVA; however, the prevalence of abnormal vestibular test findings in this patient population was not correlated with vestibular symptoms. Enlarged vestibular aqueduct size, HFPTA, and walking at a later age were correlated with abnormal vestibular test findings. In view of these results, it may be prudent to consider vestibular testing in children with these clinical characteristics. Level of Evidence: 2b. Laryngoscope, 126:2344–2350, 2016.

Original languageEnglish (US)
Pages (from-to)2344-2350
Number of pages7
JournalLaryngoscope
Volume126
Issue number10
DOIs
StatePublished - Oct 1 2016

Fingerprint

Pathology
Genetic Testing
Walking
Vestibular Evoked Myogenic Potentials
Laryngoscopes
Enlarged Vestibular Aqueduct
Temporal Bone
Vertigo
Tertiary Healthcare
Hearing Loss
Prospective Studies
Population

Keywords

  • cVEMP
  • Enlarged vestibular aqueduct
  • vertigo
  • vestibular testing
  • vestibulopathy

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Yang, C. J., Lavender, V., Meinzen-Derr, J. K., Cohen, A. P., Youssif, M., Castiglione, M., ... Greinwald, J. H. (2016). Vestibular pathology in children with enlarged vestibular aqueduct. Laryngoscope, 126(10), 2344-2350. https://doi.org/10.1002/lary.25890

Vestibular pathology in children with enlarged vestibular aqueduct. / Yang, Christina J.; Lavender, Violette; Meinzen-Derr, Jareen K.; Cohen, Aliza P.; Youssif, Mostafa; Castiglione, Micheal; Manickam, Vairavan; Bachmann, Katheryn R.; Greinwald, John H.

In: Laryngoscope, Vol. 126, No. 10, 01.10.2016, p. 2344-2350.

Research output: Contribution to journalArticle

Yang, CJ, Lavender, V, Meinzen-Derr, JK, Cohen, AP, Youssif, M, Castiglione, M, Manickam, V, Bachmann, KR & Greinwald, JH 2016, 'Vestibular pathology in children with enlarged vestibular aqueduct', Laryngoscope, vol. 126, no. 10, pp. 2344-2350. https://doi.org/10.1002/lary.25890
Yang CJ, Lavender V, Meinzen-Derr JK, Cohen AP, Youssif M, Castiglione M et al. Vestibular pathology in children with enlarged vestibular aqueduct. Laryngoscope. 2016 Oct 1;126(10):2344-2350. https://doi.org/10.1002/lary.25890
Yang, Christina J. ; Lavender, Violette ; Meinzen-Derr, Jareen K. ; Cohen, Aliza P. ; Youssif, Mostafa ; Castiglione, Micheal ; Manickam, Vairavan ; Bachmann, Katheryn R. ; Greinwald, John H. / Vestibular pathology in children with enlarged vestibular aqueduct. In: Laryngoscope. 2016 ; Vol. 126, No. 10. pp. 2344-2350.
@article{5ab4e4c11d2f441287745858a573b705,
title = "Vestibular pathology in children with enlarged vestibular aqueduct",
abstract = "Objectives/Hypothesis: To establish the prevalence of abnormal vestibular test findings in children with enlarged vestibular aqueduct (EVA) and determine if these findings correlate with clinical symptoms, radiographic findings (EVA size and laterality), audiometric findings, and genetic testing in these patients. Study Design: Prospective cohort. Methods: Patients 3 to 12 years of age with hearing loss and imaging findings consistent with EVA treated at our tertiary care institution were sequentially enrolled from 2009 to 2011. The following six outcome measurements were analyzed: audiometric findings, EVA laterality, temporal bone measurements, genetic testing, vestibular testing (cervical-evoked myogenic potentials, posturography, rotational chair, and calorics), and vestibular symptoms. Results: Twenty-seven patients with EVA (mean age 9.2 years, 48{\%} female) were enrolled in and completed the study. Vertigo was reported in six patients. Twenty-four of 27 (89{\%}) had at least one abnormal vestibular test result. Midpoint and operculum size correlated with directional preponderance (P =.042 and P =.032, respectively). Also, high-frequency pure tone average (HFPTA) correlated with unilateral weakness (P =.002). Walking at a later age correlated with abnormal posturography results. There was no correlation between EVA laterality and vestibular test findings. Conclusion: We found a high rate of vestibular pathology in children with EVA; however, the prevalence of abnormal vestibular test findings in this patient population was not correlated with vestibular symptoms. Enlarged vestibular aqueduct size, HFPTA, and walking at a later age were correlated with abnormal vestibular test findings. In view of these results, it may be prudent to consider vestibular testing in children with these clinical characteristics. Level of Evidence: 2b. Laryngoscope, 126:2344–2350, 2016.",
keywords = "cVEMP, Enlarged vestibular aqueduct, vertigo, vestibular testing, vestibulopathy",
author = "Yang, {Christina J.} and Violette Lavender and Meinzen-Derr, {Jareen K.} and Cohen, {Aliza P.} and Mostafa Youssif and Micheal Castiglione and Vairavan Manickam and Bachmann, {Katheryn R.} and Greinwald, {John H.}",
year = "2016",
month = "10",
day = "1",
doi = "10.1002/lary.25890",
language = "English (US)",
volume = "126",
pages = "2344--2350",
journal = "Laryngoscope",
issn = "0023-852X",
publisher = "John Wiley and Sons Inc.",
number = "10",

}

TY - JOUR

T1 - Vestibular pathology in children with enlarged vestibular aqueduct

AU - Yang, Christina J.

AU - Lavender, Violette

AU - Meinzen-Derr, Jareen K.

AU - Cohen, Aliza P.

AU - Youssif, Mostafa

AU - Castiglione, Micheal

AU - Manickam, Vairavan

AU - Bachmann, Katheryn R.

AU - Greinwald, John H.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Objectives/Hypothesis: To establish the prevalence of abnormal vestibular test findings in children with enlarged vestibular aqueduct (EVA) and determine if these findings correlate with clinical symptoms, radiographic findings (EVA size and laterality), audiometric findings, and genetic testing in these patients. Study Design: Prospective cohort. Methods: Patients 3 to 12 years of age with hearing loss and imaging findings consistent with EVA treated at our tertiary care institution were sequentially enrolled from 2009 to 2011. The following six outcome measurements were analyzed: audiometric findings, EVA laterality, temporal bone measurements, genetic testing, vestibular testing (cervical-evoked myogenic potentials, posturography, rotational chair, and calorics), and vestibular symptoms. Results: Twenty-seven patients with EVA (mean age 9.2 years, 48% female) were enrolled in and completed the study. Vertigo was reported in six patients. Twenty-four of 27 (89%) had at least one abnormal vestibular test result. Midpoint and operculum size correlated with directional preponderance (P =.042 and P =.032, respectively). Also, high-frequency pure tone average (HFPTA) correlated with unilateral weakness (P =.002). Walking at a later age correlated with abnormal posturography results. There was no correlation between EVA laterality and vestibular test findings. Conclusion: We found a high rate of vestibular pathology in children with EVA; however, the prevalence of abnormal vestibular test findings in this patient population was not correlated with vestibular symptoms. Enlarged vestibular aqueduct size, HFPTA, and walking at a later age were correlated with abnormal vestibular test findings. In view of these results, it may be prudent to consider vestibular testing in children with these clinical characteristics. Level of Evidence: 2b. Laryngoscope, 126:2344–2350, 2016.

AB - Objectives/Hypothesis: To establish the prevalence of abnormal vestibular test findings in children with enlarged vestibular aqueduct (EVA) and determine if these findings correlate with clinical symptoms, radiographic findings (EVA size and laterality), audiometric findings, and genetic testing in these patients. Study Design: Prospective cohort. Methods: Patients 3 to 12 years of age with hearing loss and imaging findings consistent with EVA treated at our tertiary care institution were sequentially enrolled from 2009 to 2011. The following six outcome measurements were analyzed: audiometric findings, EVA laterality, temporal bone measurements, genetic testing, vestibular testing (cervical-evoked myogenic potentials, posturography, rotational chair, and calorics), and vestibular symptoms. Results: Twenty-seven patients with EVA (mean age 9.2 years, 48% female) were enrolled in and completed the study. Vertigo was reported in six patients. Twenty-four of 27 (89%) had at least one abnormal vestibular test result. Midpoint and operculum size correlated with directional preponderance (P =.042 and P =.032, respectively). Also, high-frequency pure tone average (HFPTA) correlated with unilateral weakness (P =.002). Walking at a later age correlated with abnormal posturography results. There was no correlation between EVA laterality and vestibular test findings. Conclusion: We found a high rate of vestibular pathology in children with EVA; however, the prevalence of abnormal vestibular test findings in this patient population was not correlated with vestibular symptoms. Enlarged vestibular aqueduct size, HFPTA, and walking at a later age were correlated with abnormal vestibular test findings. In view of these results, it may be prudent to consider vestibular testing in children with these clinical characteristics. Level of Evidence: 2b. Laryngoscope, 126:2344–2350, 2016.

KW - cVEMP

KW - Enlarged vestibular aqueduct

KW - vertigo

KW - vestibular testing

KW - vestibulopathy

UR - http://www.scopus.com/inward/record.url?scp=84990233217&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84990233217&partnerID=8YFLogxK

U2 - 10.1002/lary.25890

DO - 10.1002/lary.25890

M3 - Article

C2 - 26864825

AN - SCOPUS:84990233217

VL - 126

SP - 2344

EP - 2350

JO - Laryngoscope

JF - Laryngoscope

SN - 0023-852X

IS - 10

ER -