TY - JOUR
T1 - Vesicular transport across the fungal cell wall
AU - Casadevall, Arturo
AU - Nosanchuk, Joshua D.
AU - Williamson, Peter
AU - Rodrigues, Marcio L.
N1 - Funding Information:
AC is supported by AI033774, HL059842 and AI033142; JDN is supported by NIH grants AI52733 and AI056070–01A2; PW is supported by AI49371, AI45995 and VA merit Award and MR is supported by grants from the Brazilian agencies CNPq and FAPERJ.
PY - 2009/4
Y1 - 2009/4
N2 - Recent findings indicate that fungi use vesicular transport to deliver substances across their cell walls. Fungal vesicles are similar to mammalian exosomes and could originate from cytoplasmic multivesicular bodies. Vesicular transport enables the export of large molecules across the cell wall, and vesicles contain lipids, proteins and polysaccharides, many of which are associated with virulence. Concentration of fungal products in vesicles could increase their efficiency in food acquisition and/or delivering potentially noxious substances to other cells, such as amoebae or phagocytes. The discovery of vesicular transport in fungi opens many new avenues for investigation in basic cell biology and pathogenesis.
AB - Recent findings indicate that fungi use vesicular transport to deliver substances across their cell walls. Fungal vesicles are similar to mammalian exosomes and could originate from cytoplasmic multivesicular bodies. Vesicular transport enables the export of large molecules across the cell wall, and vesicles contain lipids, proteins and polysaccharides, many of which are associated with virulence. Concentration of fungal products in vesicles could increase their efficiency in food acquisition and/or delivering potentially noxious substances to other cells, such as amoebae or phagocytes. The discovery of vesicular transport in fungi opens many new avenues for investigation in basic cell biology and pathogenesis.
UR - http://www.scopus.com/inward/record.url?scp=63349095023&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=63349095023&partnerID=8YFLogxK
U2 - 10.1016/j.tim.2008.12.005
DO - 10.1016/j.tim.2008.12.005
M3 - Article
C2 - 19299133
AN - SCOPUS:63349095023
SN - 0966-842X
VL - 17
SP - 158
EP - 162
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 4
ER -