Ventricular assist device therapy

Gabriel Sayer, Yoshifumi Naka, Ulrich P. Jorde

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


Ventricular assist devices are an important therapeutic option for advanced congestive heart failure. A left ventricular assist device (LVAD) can be implanted as a bridge to transplantation or for the purpose of destination therapy. LVADs improve end-organ function and reduce morbidity and mortality in appropriately selected patients. The development of axial flow pumps has overcome many of the limitations of the first-generation pulsatile flow LVADs. However, many complications of LVAD therapy remain. Treating these complications requires an understanding of LVAD physiology. Ongoing research is directed at reducing the incidence of many of these complications and may allow for wider use of LVADs.

Original languageEnglish (US)
Pages (from-to)140-150
Number of pages11
JournalCardiovascular Therapeutics
Issue number2
StatePublished - Jun 2009
Externally publishedYes


  • Cardiovascular physiology
  • Heart failure
  • Transplant
  • Ventricular assist devices

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)


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