Ventilatory efficiency before and after lung volume reduction surgery

Hilary F. Armstron, Nicole E. Dussault, Wilawan Thirapatarapong, Renee S. Lemieux, Byron M. Thomashow, Matthew N. Bartels

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Lung volume reduction surgery (LVRS) has been shown to improve the clearance of carbon dioxide and minute ventilation (V<inf>E</inf>) in select patients with COPD. One variable often assessed in COPD is ventilatory efficiency (V<inf>E</inf>/V<inf>CO2</inf>). Methods: We compared 55 LVRS subjects with 25 controls from the National Emphysema Treatment Trial. V<inf>E</inf>/V<inf>CO2</inf> was calculated from cardiopulmonary exercise testing at baseline and 6-months. We sought to assess V<inf>E</inf>/<inf>CO2</inf>changes with LVRS compared with controls who only received standard medical care. Results: At 6 months, the LVRS group significantly increased peak V<inf>O2</inf>, work load, V<inf>E</inf>, V<inf>CO2</inf>, and tidal volume while lowering peak and lowest V<inf>E</inf>/<inf>CO2</inf>(improved ventilatory efficiency) and end-tidal carbon dioxide pressure. The control group did not display these changes. The changes were greatest in the LVRS subjects who improved their exercise capacity after surgery (> 10 W). Conclusions: The changes were greatest in the LVRS subjects who showed the most functional improvement, indicating an association of improved ventilation with improved functional outcome.

Original languageEnglish (US)
Pages (from-to)63-71
Number of pages9
JournalRespiratory Care
Volume60
Issue number1
DOIs
StatePublished - 2015

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Pneumonectomy
Ventilation
Carbon Dioxide
Chronic Obstructive Pulmonary Disease
Exercise
Tidal Volume
Emphysema
Workload
Pressure
Control Groups

Keywords

  • Chronic obstructive pulmonary disease
  • Exercise
  • Gas exchange

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Medicine(all)

Cite this

Armstron, H. F., Dussault, N. E., Thirapatarapong, W., Lemieux, R. S., Thomashow, B. M., & Bartels, M. N. (2015). Ventilatory efficiency before and after lung volume reduction surgery. Respiratory Care, 60(1), 63-71. https://doi.org/10.4187/respcare.03233

Ventilatory efficiency before and after lung volume reduction surgery. / Armstron, Hilary F.; Dussault, Nicole E.; Thirapatarapong, Wilawan; Lemieux, Renee S.; Thomashow, Byron M.; Bartels, Matthew N.

In: Respiratory Care, Vol. 60, No. 1, 2015, p. 63-71.

Research output: Contribution to journalArticle

Armstron, HF, Dussault, NE, Thirapatarapong, W, Lemieux, RS, Thomashow, BM & Bartels, MN 2015, 'Ventilatory efficiency before and after lung volume reduction surgery', Respiratory Care, vol. 60, no. 1, pp. 63-71. https://doi.org/10.4187/respcare.03233
Armstron HF, Dussault NE, Thirapatarapong W, Lemieux RS, Thomashow BM, Bartels MN. Ventilatory efficiency before and after lung volume reduction surgery. Respiratory Care. 2015;60(1):63-71. https://doi.org/10.4187/respcare.03233
Armstron, Hilary F. ; Dussault, Nicole E. ; Thirapatarapong, Wilawan ; Lemieux, Renee S. ; Thomashow, Byron M. ; Bartels, Matthew N. / Ventilatory efficiency before and after lung volume reduction surgery. In: Respiratory Care. 2015 ; Vol. 60, No. 1. pp. 63-71.
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