Ventilatory efficiency before and after lung volume reduction surgery

Hilary F. Armstron; Nicole E. Dussault; Wilawan Thirapatarapong; Renee S. Lemieux; Byron M. Thomashow; Matthew N. Bartels

doi:10.4187/respcare.03233

Ventilatory efficiency before and after lung volume reduction surgery

Hilary F. Armstron, Nicole E. Dussault, Wilawan Thirapatarapong, Renee S. Lemieux, Byron M. Thomashow, Matthew N. Bartels

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Background: Lung volume reduction surgery (LVRS) has been shown to improve the clearance of carbon dioxide and minute ventilation (V_E) in select patients with COPD. One variable often assessed in COPD is ventilatory efficiency (V_E/V_CO2). Methods: We compared 55 LVRS subjects with 25 controls from the National Emphysema Treatment Trial. V_E/V_CO2 was calculated from cardiopulmonary exercise testing at baseline and 6-months. We sought to assess V_E/_CO2changes with LVRS compared with controls who only received standard medical care. Results: At 6 months, the LVRS group significantly increased peak V_O2, work load, V_E, V_CO2, and tidal volume while lowering peak and lowest V_E/_CO2(improved ventilatory efficiency) and end-tidal carbon dioxide pressure. The control group did not display these changes. The changes were greatest in the LVRS subjects who improved their exercise capacity after surgery (> 10 W). Conclusions: The changes were greatest in the LVRS subjects who showed the most functional improvement, indicating an association of improved ventilation with improved functional outcome.

Original language	English (US)
Pages (from-to)	63-71
Number of pages	9
Journal	Respiratory care
Volume	60
Issue number	1
DOIs	https://doi.org/10.4187/respcare.03233
State	Published - 2015

Keywords

Chronic obstructive pulmonary disease
Exercise
Gas exchange

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine

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10.4187/respcare.03233

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title = "Ventilatory efficiency before and after lung volume reduction surgery",

abstract = "Background: Lung volume reduction surgery (LVRS) has been shown to improve the clearance of carbon dioxide and minute ventilation (VE) in select patients with COPD. One variable often assessed in COPD is ventilatory efficiency (VE/VCO2). Methods: We compared 55 LVRS subjects with 25 controls from the National Emphysema Treatment Trial. VE/VCO2 was calculated from cardiopulmonary exercise testing at baseline and 6-months. We sought to assess VE/CO2changes with LVRS compared with controls who only received standard medical care. Results: At 6 months, the LVRS group significantly increased peak VO2, work load, VE, VCO2, and tidal volume while lowering peak and lowest VE/CO2(improved ventilatory efficiency) and end-tidal carbon dioxide pressure. The control group did not display these changes. The changes were greatest in the LVRS subjects who improved their exercise capacity after surgery (> 10 W). Conclusions: The changes were greatest in the LVRS subjects who showed the most functional improvement, indicating an association of improved ventilation with improved functional outcome.",

keywords = "Chronic obstructive pulmonary disease, Exercise, Gas exchange",

author = "Armstron, {Hilary F.} and Dussault, {Nicole E.} and Wilawan Thirapatarapong and Lemieux, {Renee S.} and Thomashow, {Byron M.} and Bartels, {Matthew N.}",

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year = "2015",

doi = "10.4187/respcare.03233",

language = "English (US)",

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pages = "63--71",

journal = "Respiratory care",

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T1 - Ventilatory efficiency before and after lung volume reduction surgery

AU - Armstron, Hilary F.

AU - Dussault, Nicole E.

AU - Thirapatarapong, Wilawan

AU - Lemieux, Renee S.

AU - Thomashow, Byron M.

AU - Bartels, Matthew N.

PY - 2015

Y1 - 2015

N2 - Background: Lung volume reduction surgery (LVRS) has been shown to improve the clearance of carbon dioxide and minute ventilation (VE) in select patients with COPD. One variable often assessed in COPD is ventilatory efficiency (VE/VCO2). Methods: We compared 55 LVRS subjects with 25 controls from the National Emphysema Treatment Trial. VE/VCO2 was calculated from cardiopulmonary exercise testing at baseline and 6-months. We sought to assess VE/CO2changes with LVRS compared with controls who only received standard medical care. Results: At 6 months, the LVRS group significantly increased peak VO2, work load, VE, VCO2, and tidal volume while lowering peak and lowest VE/CO2(improved ventilatory efficiency) and end-tidal carbon dioxide pressure. The control group did not display these changes. The changes were greatest in the LVRS subjects who improved their exercise capacity after surgery (> 10 W). Conclusions: The changes were greatest in the LVRS subjects who showed the most functional improvement, indicating an association of improved ventilation with improved functional outcome.

AB - Background: Lung volume reduction surgery (LVRS) has been shown to improve the clearance of carbon dioxide and minute ventilation (VE) in select patients with COPD. One variable often assessed in COPD is ventilatory efficiency (VE/VCO2). Methods: We compared 55 LVRS subjects with 25 controls from the National Emphysema Treatment Trial. VE/VCO2 was calculated from cardiopulmonary exercise testing at baseline and 6-months. We sought to assess VE/CO2changes with LVRS compared with controls who only received standard medical care. Results: At 6 months, the LVRS group significantly increased peak VO2, work load, VE, VCO2, and tidal volume while lowering peak and lowest VE/CO2(improved ventilatory efficiency) and end-tidal carbon dioxide pressure. The control group did not display these changes. The changes were greatest in the LVRS subjects who improved their exercise capacity after surgery (> 10 W). Conclusions: The changes were greatest in the LVRS subjects who showed the most functional improvement, indicating an association of improved ventilation with improved functional outcome.

KW - Chronic obstructive pulmonary disease

KW - Exercise

KW - Gas exchange

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Ventilatory efficiency before and after lung volume reduction surgery

Abstract

Keywords

ASJC Scopus subject areas

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