Varying features of early age-of-onset 'sporadic' and hereditary nonpolyposis colorectal cancer patients

Jose G. Guillem, Jorge Puig La Calle, Christina Cellini, Melissa Murray, Jeremy Ng, Melissa Fazzari, Philip B. Paty, Stuart H.Q. Quan, W. Douglas Wong, Alfred M. Cohen

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

PURPOSE: Although the criteria for clinical diagnosis of hereditary nonpolyposis colorectal cancer are not fully agreed on, young age seems to be a common trait. The purpose of this study is to identify clinicopathologic features of hereditary nonpolyposis colorectal cancer in early age-of-onset colorectal cancer patients stratified as a function of family cancer history. METHODS: Two hundred thirty consecutive colorectal cancer patients 40 years or older at time of diagnosis were registered into an ongoing database during a ten-year period. Accurate family history was obtained via medical records, telephone calls, and questionnaires on 146 patients. According to extent of family history of cancer, patients were stratified into seven groups: 1) fulfilling Amsterdam criteria, 2) fulfilling less strict criteria, 3) having at least one first-degree relative with colorectal cancer, 4) having at least one distant relative with colorectal cancer, 5) having at least one first- degree relative with any cancer, 6) having at least one distant relative with any cancer, 7) having no family history of cancer. RESULTS: Twenty-two of 146 patients fulfilled Amsterdam and less strict hereditary nonpolyposis colorectal cancer criteria (15 percent). These hereditary nonpolyposis colorectal cancer patients were significantly younger (31 vs. 35 years; P = 0.0003) and had more metachronous colorectal cancer (27 percent vs. 2 percent; P = 0.007) and less colorectal cancer with nodal or metastatic spread than the non-hereditary nonpolyposis colorectal cancer patients (35 percent vs. 65 percent; P = 0.01). CONCLUSION: Precise familial cancer assessment in early age-of-onset colorectal cancer increases the yield of hereditary nonpolyposis colorectal cancer diagnosis. Because of the frequent development of metachronous colorectal cancer and favorable prognosis, extensive rather than segmental surgery should be considered in early age- of-onset colorectal cancer patients belonging to hereditary nonpolyposis colorectal cancer families.

Original languageEnglish (US)
Pages (from-to)36-42
Number of pages7
JournalDiseases of the Colon and Rectum
Volume42
Issue number1
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

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Hereditary Nonpolyposis Colorectal Neoplasms
Age of Onset
Colorectal Neoplasms
Neoplasms
Telephone
Medical Records
Databases

Keywords

  • Early age-of-onset colorectal cancer
  • Family history
  • Hereditary nonpolyposis colorectal cancer
  • Prophylactic surgery

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Varying features of early age-of-onset 'sporadic' and hereditary nonpolyposis colorectal cancer patients. / Guillem, Jose G.; Calle, Jorge Puig La; Cellini, Christina; Murray, Melissa; Ng, Jeremy; Fazzari, Melissa; Paty, Philip B.; Quan, Stuart H.Q.; Wong, W. Douglas; Cohen, Alfred M.

In: Diseases of the Colon and Rectum, Vol. 42, No. 1, 01.01.1999, p. 36-42.

Research output: Contribution to journalArticle

Guillem, JG, Calle, JPL, Cellini, C, Murray, M, Ng, J, Fazzari, M, Paty, PB, Quan, SHQ, Wong, WD & Cohen, AM 1999, 'Varying features of early age-of-onset 'sporadic' and hereditary nonpolyposis colorectal cancer patients', Diseases of the Colon and Rectum, vol. 42, no. 1, pp. 36-42. https://doi.org/10.1007/BF02235180
Guillem, Jose G. ; Calle, Jorge Puig La ; Cellini, Christina ; Murray, Melissa ; Ng, Jeremy ; Fazzari, Melissa ; Paty, Philip B. ; Quan, Stuart H.Q. ; Wong, W. Douglas ; Cohen, Alfred M. / Varying features of early age-of-onset 'sporadic' and hereditary nonpolyposis colorectal cancer patients. In: Diseases of the Colon and Rectum. 1999 ; Vol. 42, No. 1. pp. 36-42.
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AU - Guillem, Jose G.

AU - Calle, Jorge Puig La

AU - Cellini, Christina

AU - Murray, Melissa

AU - Ng, Jeremy

AU - Fazzari, Melissa

AU - Paty, Philip B.

AU - Quan, Stuart H.Q.

AU - Wong, W. Douglas

AU - Cohen, Alfred M.

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N2 - PURPOSE: Although the criteria for clinical diagnosis of hereditary nonpolyposis colorectal cancer are not fully agreed on, young age seems to be a common trait. The purpose of this study is to identify clinicopathologic features of hereditary nonpolyposis colorectal cancer in early age-of-onset colorectal cancer patients stratified as a function of family cancer history. METHODS: Two hundred thirty consecutive colorectal cancer patients 40 years or older at time of diagnosis were registered into an ongoing database during a ten-year period. Accurate family history was obtained via medical records, telephone calls, and questionnaires on 146 patients. According to extent of family history of cancer, patients were stratified into seven groups: 1) fulfilling Amsterdam criteria, 2) fulfilling less strict criteria, 3) having at least one first-degree relative with colorectal cancer, 4) having at least one distant relative with colorectal cancer, 5) having at least one first- degree relative with any cancer, 6) having at least one distant relative with any cancer, 7) having no family history of cancer. RESULTS: Twenty-two of 146 patients fulfilled Amsterdam and less strict hereditary nonpolyposis colorectal cancer criteria (15 percent). These hereditary nonpolyposis colorectal cancer patients were significantly younger (31 vs. 35 years; P = 0.0003) and had more metachronous colorectal cancer (27 percent vs. 2 percent; P = 0.007) and less colorectal cancer with nodal or metastatic spread than the non-hereditary nonpolyposis colorectal cancer patients (35 percent vs. 65 percent; P = 0.01). CONCLUSION: Precise familial cancer assessment in early age-of-onset colorectal cancer increases the yield of hereditary nonpolyposis colorectal cancer diagnosis. Because of the frequent development of metachronous colorectal cancer and favorable prognosis, extensive rather than segmental surgery should be considered in early age- of-onset colorectal cancer patients belonging to hereditary nonpolyposis colorectal cancer families.

AB - PURPOSE: Although the criteria for clinical diagnosis of hereditary nonpolyposis colorectal cancer are not fully agreed on, young age seems to be a common trait. The purpose of this study is to identify clinicopathologic features of hereditary nonpolyposis colorectal cancer in early age-of-onset colorectal cancer patients stratified as a function of family cancer history. METHODS: Two hundred thirty consecutive colorectal cancer patients 40 years or older at time of diagnosis were registered into an ongoing database during a ten-year period. Accurate family history was obtained via medical records, telephone calls, and questionnaires on 146 patients. According to extent of family history of cancer, patients were stratified into seven groups: 1) fulfilling Amsterdam criteria, 2) fulfilling less strict criteria, 3) having at least one first-degree relative with colorectal cancer, 4) having at least one distant relative with colorectal cancer, 5) having at least one first- degree relative with any cancer, 6) having at least one distant relative with any cancer, 7) having no family history of cancer. RESULTS: Twenty-two of 146 patients fulfilled Amsterdam and less strict hereditary nonpolyposis colorectal cancer criteria (15 percent). These hereditary nonpolyposis colorectal cancer patients were significantly younger (31 vs. 35 years; P = 0.0003) and had more metachronous colorectal cancer (27 percent vs. 2 percent; P = 0.007) and less colorectal cancer with nodal or metastatic spread than the non-hereditary nonpolyposis colorectal cancer patients (35 percent vs. 65 percent; P = 0.01). CONCLUSION: Precise familial cancer assessment in early age-of-onset colorectal cancer increases the yield of hereditary nonpolyposis colorectal cancer diagnosis. Because of the frequent development of metachronous colorectal cancer and favorable prognosis, extensive rather than segmental surgery should be considered in early age- of-onset colorectal cancer patients belonging to hereditary nonpolyposis colorectal cancer families.

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KW - Prophylactic surgery

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