Variations in the synthesis and assembly of immunoglobulins by mouse myeloma cells: A genetic and biochemical analysis

M. D. Scharff, A. Bargellesi, R. Baumal, J. Buxbaum, P. Coffino, R. Laskov

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Abstract

The synthesis, assembly, and secretion of gamma globulin has been examined using cells from a mouse plasma cell tumor. The cells were then adapted to continuous culture and individual clones were obtained which differed from each other in the relative amounts of heavy and light chains synthesized, in the absolute amounts of gamma globulin being produced, and in the details of the assembly process. Finally, the kinetics, pathway, and completeness of assembly were examined in a variety of tumors and variants of these tumors.

Original languageEnglish (US)
Pages (from-to)331-348
Number of pages18
JournalJournal of Cellular Physiology
Volume76
Issue number3
DOIs
Publication statusPublished - Dec 1970

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ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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