Variations in the contouring of organs at risk: Test case from a patient with oropharyngeal cancer

Benjamin E. Nelms, Wolfgang A. Tome, Greg Robinson, James Wheeler

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Purpose: Anatomy contouring is critical in radiation therapy. Inaccuracy and variation in defining critical volumes will affect everything downstream: treatment planning, dose-volume histogram analysis, and contour-based visual guidance used in image-guided radiation therapy. This study quantified: (1) variation in the contouring of organs at risk (OAR) in a clinical test case and (2) corresponding effects on dosimetric metrics of highly conformal plans. Methods and Materials: A common CT data set with predefined targets from a patient with oropharyngeal cancer was provided to a population of clinics, which were asked to (1) contour OARs and (2) design an intensity-modulated radiation therapy plan. Thirty-two acceptable plans were submitted as DICOM RT data sets, each generated by a different clinical team. Using those data sets, we quantified: (1) the OAR contouring variation and (2) the impact this variation has on dosimetric metrics. New technologies were employed, including a software tool to quantify three-dimensional structure comparisons. Results: There was significant interclinician variation in OAR contouring. The degree of variation is organ-dependent. We found substantial dose differences resulting strictly from contouring variation (differences ranging from -289% to 56% for mean OAR dose; -22% to 35% for maximum dose). However, there appears to be a threshold in the OAR comparison metric beyond which the dose differences stabilize. Conclusions: The effects of interclinician variation in contouring organs-at-risk in the head and neck can be large and are organ-specific. Physicians need to be aware of the effect that variation in OAR contouring can play on the final treatment plan and not restrict their focus only to the target volumes.

Original languageEnglish (US)
Pages (from-to)368-378
Number of pages11
JournalInternational Journal of Radiation Oncology Biology Physics
Volume82
Issue number1
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

Fingerprint

Oropharyngeal Neoplasms
Organs at Risk
organs
cancer
dosage
radiation therapy
Radiotherapy
Image-Guided Radiotherapy
physicians
software development tools
anatomy
Anatomy
Neck
Software
histograms
Head
planning
Technology
Physicians
Therapeutics

Keywords

  • Conformal Therapy
  • Contouring
  • IMRT
  • Quality Assurance
  • Treatment Planning

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research

Cite this

Variations in the contouring of organs at risk : Test case from a patient with oropharyngeal cancer. / Nelms, Benjamin E.; Tome, Wolfgang A.; Robinson, Greg; Wheeler, James.

In: International Journal of Radiation Oncology Biology Physics, Vol. 82, No. 1, 01.01.2012, p. 368-378.

Research output: Contribution to journalArticle

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