Variations in serum müllerian inhibiting substance between white, black, and Hispanic women

David B. Seifer, Elizabeth T. Golub, Geralyn Lambert-Messerlian, Lorie Benning, Kathryn Anastos, D. Heather Watts, Mardge H. Cohen, Roksana Karim, Mary A. Young, Howard Minkoff, Ruth M. Greenblatt

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Objective: To compare serum müllerian inhibiting substance (MIS) levels between white, black, and Hispanic women to determine whether ovarian aging occurs at a different time course for women of different racial groups. Design: Longitudinal study of serum MIS levels in women of different race and ethnicity over two different time points. Setting: Women's Interagency HIV Study, a multicenter prospective cohort study. Patient(s): Serum samples obtained from 809 participants (122 white, 462 black, and 225 Hispanic women). Intervention(s): Comparison of serum MIS between women of different race and ethnicity at two time points (median age 37.5 years and 43.3 years). Main Outcome Measure(s): Variation in MIS by race and ethnicity over time, controlling for age, body mass index, HIV status, and smoking. Result(s): Compared with white women, average MIS values were lower among black (25.2% lower) and Hispanic (24.6% lower) women, adjusting for age, body mass index, smoking, and HIV status. Conclusion(s): There is an independent effect of race and ethnicity on the age-related decline in MIS over time.

Original languageEnglish (US)
Pages (from-to)1674-1678
Number of pages5
JournalFertility and Sterility
Volume92
Issue number5
DOIs
StatePublished - Nov 2009

Fingerprint

Hispanic Americans
Serum
HIV
Body Mass Index
Smoking
hydroquinone
Multicenter Studies
Longitudinal Studies
Cohort Studies
Outcome Assessment (Health Care)
Prospective Studies

Keywords

  • antimüllerian hormone
  • ethnicity
  • Müllerian inhibiting substance
  • ovarian reserve
  • race

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Seifer, D. B., Golub, E. T., Lambert-Messerlian, G., Benning, L., Anastos, K., Watts, D. H., ... Greenblatt, R. M. (2009). Variations in serum müllerian inhibiting substance between white, black, and Hispanic women. Fertility and Sterility, 92(5), 1674-1678. https://doi.org/10.1016/j.fertnstert.2008.08.110

Variations in serum müllerian inhibiting substance between white, black, and Hispanic women. / Seifer, David B.; Golub, Elizabeth T.; Lambert-Messerlian, Geralyn; Benning, Lorie; Anastos, Kathryn; Watts, D. Heather; Cohen, Mardge H.; Karim, Roksana; Young, Mary A.; Minkoff, Howard; Greenblatt, Ruth M.

In: Fertility and Sterility, Vol. 92, No. 5, 11.2009, p. 1674-1678.

Research output: Contribution to journalArticle

Seifer, DB, Golub, ET, Lambert-Messerlian, G, Benning, L, Anastos, K, Watts, DH, Cohen, MH, Karim, R, Young, MA, Minkoff, H & Greenblatt, RM 2009, 'Variations in serum müllerian inhibiting substance between white, black, and Hispanic women', Fertility and Sterility, vol. 92, no. 5, pp. 1674-1678. https://doi.org/10.1016/j.fertnstert.2008.08.110
Seifer, David B. ; Golub, Elizabeth T. ; Lambert-Messerlian, Geralyn ; Benning, Lorie ; Anastos, Kathryn ; Watts, D. Heather ; Cohen, Mardge H. ; Karim, Roksana ; Young, Mary A. ; Minkoff, Howard ; Greenblatt, Ruth M. / Variations in serum müllerian inhibiting substance between white, black, and Hispanic women. In: Fertility and Sterility. 2009 ; Vol. 92, No. 5. pp. 1674-1678.
@article{a5e13d6f5e7a4102b95de483bc04eda5,
title = "Variations in serum m{\"u}llerian inhibiting substance between white, black, and Hispanic women",
abstract = "Objective: To compare serum m{\"u}llerian inhibiting substance (MIS) levels between white, black, and Hispanic women to determine whether ovarian aging occurs at a different time course for women of different racial groups. Design: Longitudinal study of serum MIS levels in women of different race and ethnicity over two different time points. Setting: Women's Interagency HIV Study, a multicenter prospective cohort study. Patient(s): Serum samples obtained from 809 participants (122 white, 462 black, and 225 Hispanic women). Intervention(s): Comparison of serum MIS between women of different race and ethnicity at two time points (median age 37.5 years and 43.3 years). Main Outcome Measure(s): Variation in MIS by race and ethnicity over time, controlling for age, body mass index, HIV status, and smoking. Result(s): Compared with white women, average MIS values were lower among black (25.2{\%} lower) and Hispanic (24.6{\%} lower) women, adjusting for age, body mass index, smoking, and HIV status. Conclusion(s): There is an independent effect of race and ethnicity on the age-related decline in MIS over time.",
keywords = "antim{\"u}llerian hormone, ethnicity, M{\"u}llerian inhibiting substance, ovarian reserve, race",
author = "Seifer, {David B.} and Golub, {Elizabeth T.} and Geralyn Lambert-Messerlian and Lorie Benning and Kathryn Anastos and Watts, {D. Heather} and Cohen, {Mardge H.} and Roksana Karim and Young, {Mary A.} and Howard Minkoff and Greenblatt, {Ruth M.}",
year = "2009",
month = "11",
doi = "10.1016/j.fertnstert.2008.08.110",
language = "English (US)",
volume = "92",
pages = "1674--1678",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Variations in serum müllerian inhibiting substance between white, black, and Hispanic women

AU - Seifer, David B.

AU - Golub, Elizabeth T.

AU - Lambert-Messerlian, Geralyn

AU - Benning, Lorie

AU - Anastos, Kathryn

AU - Watts, D. Heather

AU - Cohen, Mardge H.

AU - Karim, Roksana

AU - Young, Mary A.

AU - Minkoff, Howard

AU - Greenblatt, Ruth M.

PY - 2009/11

Y1 - 2009/11

N2 - Objective: To compare serum müllerian inhibiting substance (MIS) levels between white, black, and Hispanic women to determine whether ovarian aging occurs at a different time course for women of different racial groups. Design: Longitudinal study of serum MIS levels in women of different race and ethnicity over two different time points. Setting: Women's Interagency HIV Study, a multicenter prospective cohort study. Patient(s): Serum samples obtained from 809 participants (122 white, 462 black, and 225 Hispanic women). Intervention(s): Comparison of serum MIS between women of different race and ethnicity at two time points (median age 37.5 years and 43.3 years). Main Outcome Measure(s): Variation in MIS by race and ethnicity over time, controlling for age, body mass index, HIV status, and smoking. Result(s): Compared with white women, average MIS values were lower among black (25.2% lower) and Hispanic (24.6% lower) women, adjusting for age, body mass index, smoking, and HIV status. Conclusion(s): There is an independent effect of race and ethnicity on the age-related decline in MIS over time.

AB - Objective: To compare serum müllerian inhibiting substance (MIS) levels between white, black, and Hispanic women to determine whether ovarian aging occurs at a different time course for women of different racial groups. Design: Longitudinal study of serum MIS levels in women of different race and ethnicity over two different time points. Setting: Women's Interagency HIV Study, a multicenter prospective cohort study. Patient(s): Serum samples obtained from 809 participants (122 white, 462 black, and 225 Hispanic women). Intervention(s): Comparison of serum MIS between women of different race and ethnicity at two time points (median age 37.5 years and 43.3 years). Main Outcome Measure(s): Variation in MIS by race and ethnicity over time, controlling for age, body mass index, HIV status, and smoking. Result(s): Compared with white women, average MIS values were lower among black (25.2% lower) and Hispanic (24.6% lower) women, adjusting for age, body mass index, smoking, and HIV status. Conclusion(s): There is an independent effect of race and ethnicity on the age-related decline in MIS over time.

KW - antimüllerian hormone

KW - ethnicity

KW - Müllerian inhibiting substance

KW - ovarian reserve

KW - race

UR - http://www.scopus.com/inward/record.url?scp=70350749638&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350749638&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2008.08.110

DO - 10.1016/j.fertnstert.2008.08.110

M3 - Article

C2 - 18930217

AN - SCOPUS:70350749638

VL - 92

SP - 1674

EP - 1678

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 5

ER -