Variations in serum müllerian inhibiting substance between white, black, and Hispanic women

David B. Seifer, Elizabeth T. Golub, Geralyn Lambert-Messerlian, Lorie Benning, Kathryn Anastos, D. Heather Watts, Mardge H. Cohen, Roksana Karim, Mary A. Young, Howard Minkoff, Ruth M. Greenblatt

Research output: Contribution to journalArticlepeer-review

98 Scopus citations

Abstract

Objective: To compare serum müllerian inhibiting substance (MIS) levels between white, black, and Hispanic women to determine whether ovarian aging occurs at a different time course for women of different racial groups. Design: Longitudinal study of serum MIS levels in women of different race and ethnicity over two different time points. Setting: Women's Interagency HIV Study, a multicenter prospective cohort study. Patient(s): Serum samples obtained from 809 participants (122 white, 462 black, and 225 Hispanic women). Intervention(s): Comparison of serum MIS between women of different race and ethnicity at two time points (median age 37.5 years and 43.3 years). Main Outcome Measure(s): Variation in MIS by race and ethnicity over time, controlling for age, body mass index, HIV status, and smoking. Result(s): Compared with white women, average MIS values were lower among black (25.2% lower) and Hispanic (24.6% lower) women, adjusting for age, body mass index, smoking, and HIV status. Conclusion(s): There is an independent effect of race and ethnicity on the age-related decline in MIS over time.

Original languageEnglish (US)
Pages (from-to)1674-1678
Number of pages5
JournalFertility and sterility
Volume92
Issue number5
DOIs
StatePublished - Nov 2009

Keywords

  • Müllerian inhibiting substance
  • antimüllerian hormone
  • ethnicity
  • ovarian reserve
  • race

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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