Variation of gap junction sensitivity to H ions with time of day

A. P. Moreno; F. Ramon; D. C. Spray

doi:10.1016/0006-8993(87)90669-X

Variation of gap junction sensitivity to H ions with time of day

A. P. Moreno, F. Ramon, D. C. Spray

Neuroscience

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Conductance of gap junctions between segments of the lateral axons of the crayfish nerve cord is reduced by cytoplasmic acidification. Simultaneous measurements of axoplasmic pH and junctional conductance at 09.00 and 12.00 h revealed a shift of about 0.25 pH units in the apparent pK of the crayfish electronic synapse. These findings indicate that gating mechanisms of gap junctions are not fixed properties, but may rather be modulated by other, possibly humoral, factors.

Original language	English (US)
Pages (from-to)	181-184
Number of pages	4
Journal	Brain research
Volume	400
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(87)90669-X
State	Published - Jan 1 1987

Keywords

Diurnal rhythm
Electrotonic synapse
Gap junction
pH

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(87)90669-X

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abstract = "Conductance of gap junctions between segments of the lateral axons of the crayfish nerve cord is reduced by cytoplasmic acidification. Simultaneous measurements of axoplasmic pH and junctional conductance at 09.00 and 12.00 h revealed a shift of about 0.25 pH units in the apparent pK of the crayfish electronic synapse. These findings indicate that gating mechanisms of gap junctions are not fixed properties, but may rather be modulated by other, possibly humoral, factors.",

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AU - Ramon, F.

AU - Spray, D. C.

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N2 - Conductance of gap junctions between segments of the lateral axons of the crayfish nerve cord is reduced by cytoplasmic acidification. Simultaneous measurements of axoplasmic pH and junctional conductance at 09.00 and 12.00 h revealed a shift of about 0.25 pH units in the apparent pK of the crayfish electronic synapse. These findings indicate that gating mechanisms of gap junctions are not fixed properties, but may rather be modulated by other, possibly humoral, factors.

AB - Conductance of gap junctions between segments of the lateral axons of the crayfish nerve cord is reduced by cytoplasmic acidification. Simultaneous measurements of axoplasmic pH and junctional conductance at 09.00 and 12.00 h revealed a shift of about 0.25 pH units in the apparent pK of the crayfish electronic synapse. These findings indicate that gating mechanisms of gap junctions are not fixed properties, but may rather be modulated by other, possibly humoral, factors.

KW - Diurnal rhythm

KW - Electrotonic synapse

KW - Gap junction

KW - pH

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Variation of gap junction sensitivity to H ions with time of day

Abstract

Keywords

ASJC Scopus subject areas

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