Variation in the interaction between familial and reproductive factors on the risk of breast cancer according to age, menopausal status, and degree of familiality

N. Andrieu, T. Prevost, Thomas E. Rohan, E. Luporsi, M. G. Lê, M. Gerber, D. G. Zaridze, Y. Lifanova, R. Renaud, H. P. Lee, S. W. Duffy

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background. Studies have found that reproductive factors might have a variable effect on the occurence of breast cancer (BC) according to the existence or not of a family history of BC. The effect of a family history of BC on the risk of BC may also vary according to the age at diagnosis and the degree of kinship. This may confound the relation between familial risk and reproductive factors. A combined analysis was performed to study the interaction between familial risk and reproductive factors according to degree of familiality, age at interview and menopausal status. Methods. The present analysis included 2948 cases and 4170 controls in seven case-control studies from four countries. The combined relative risks were estimated using a Bayesian random-effects logistic regression model. Results. The main effects of reproductive life factors on the risk of BC are in agreement with previous studies. Two-way interactions between subject's age or menopausal status and a family history of BC were not significant. Although the three-way interaction between age, familial risk and parity was not significant, familial risk seemed to be increased slightly for women with high parity compared with women with low parity in the older age group, and seemed to be slightly decreased for women with high parity compared with women with low parity in younger women. The subject's age also appeared to have an effect on the interaction between familial risk and the age at first childbirth (P = 0.1). Conclusions. A possible influence of reproductive and menstrual factors on familial risk of BC has been suggested previously and was also evident in the present study. Three-way interactions between age, family history and parity or age at first childbirth might exist and they merit further investigation.

Original languageEnglish (US)
Pages (from-to)214-223
Number of pages10
JournalInternational Journal of Epidemiology
Volume29
Issue number2
StatePublished - 2000
Externally publishedYes

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Parity
Breast Neoplasms
Logistic Models
Parturition
Case-Control Studies
Age Groups
Interviews

Keywords

  • Breast cancer
  • Familial risk
  • Interactions
  • Reproductive factors

ASJC Scopus subject areas

  • Epidemiology

Cite this

Variation in the interaction between familial and reproductive factors on the risk of breast cancer according to age, menopausal status, and degree of familiality. / Andrieu, N.; Prevost, T.; Rohan, Thomas E.; Luporsi, E.; Lê, M. G.; Gerber, M.; Zaridze, D. G.; Lifanova, Y.; Renaud, R.; Lee, H. P.; Duffy, S. W.

In: International Journal of Epidemiology, Vol. 29, No. 2, 2000, p. 214-223.

Research output: Contribution to journalArticle

Andrieu, N, Prevost, T, Rohan, TE, Luporsi, E, Lê, MG, Gerber, M, Zaridze, DG, Lifanova, Y, Renaud, R, Lee, HP & Duffy, SW 2000, 'Variation in the interaction between familial and reproductive factors on the risk of breast cancer according to age, menopausal status, and degree of familiality', International Journal of Epidemiology, vol. 29, no. 2, pp. 214-223.
Andrieu, N. ; Prevost, T. ; Rohan, Thomas E. ; Luporsi, E. ; Lê, M. G. ; Gerber, M. ; Zaridze, D. G. ; Lifanova, Y. ; Renaud, R. ; Lee, H. P. ; Duffy, S. W. / Variation in the interaction between familial and reproductive factors on the risk of breast cancer according to age, menopausal status, and degree of familiality. In: International Journal of Epidemiology. 2000 ; Vol. 29, No. 2. pp. 214-223.
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abstract = "Background. Studies have found that reproductive factors might have a variable effect on the occurence of breast cancer (BC) according to the existence or not of a family history of BC. The effect of a family history of BC on the risk of BC may also vary according to the age at diagnosis and the degree of kinship. This may confound the relation between familial risk and reproductive factors. A combined analysis was performed to study the interaction between familial risk and reproductive factors according to degree of familiality, age at interview and menopausal status. Methods. The present analysis included 2948 cases and 4170 controls in seven case-control studies from four countries. The combined relative risks were estimated using a Bayesian random-effects logistic regression model. Results. The main effects of reproductive life factors on the risk of BC are in agreement with previous studies. Two-way interactions between subject's age or menopausal status and a family history of BC were not significant. Although the three-way interaction between age, familial risk and parity was not significant, familial risk seemed to be increased slightly for women with high parity compared with women with low parity in the older age group, and seemed to be slightly decreased for women with high parity compared with women with low parity in younger women. The subject's age also appeared to have an effect on the interaction between familial risk and the age at first childbirth (P = 0.1). Conclusions. A possible influence of reproductive and menstrual factors on familial risk of BC has been suggested previously and was also evident in the present study. Three-way interactions between age, family history and parity or age at first childbirth might exist and they merit further investigation.",
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AU - Andrieu, N.

AU - Prevost, T.

AU - Rohan, Thomas E.

AU - Luporsi, E.

AU - Lê, M. G.

AU - Gerber, M.

AU - Zaridze, D. G.

AU - Lifanova, Y.

AU - Renaud, R.

AU - Lee, H. P.

AU - Duffy, S. W.

PY - 2000

Y1 - 2000

N2 - Background. Studies have found that reproductive factors might have a variable effect on the occurence of breast cancer (BC) according to the existence or not of a family history of BC. The effect of a family history of BC on the risk of BC may also vary according to the age at diagnosis and the degree of kinship. This may confound the relation between familial risk and reproductive factors. A combined analysis was performed to study the interaction between familial risk and reproductive factors according to degree of familiality, age at interview and menopausal status. Methods. The present analysis included 2948 cases and 4170 controls in seven case-control studies from four countries. The combined relative risks were estimated using a Bayesian random-effects logistic regression model. Results. The main effects of reproductive life factors on the risk of BC are in agreement with previous studies. Two-way interactions between subject's age or menopausal status and a family history of BC were not significant. Although the three-way interaction between age, familial risk and parity was not significant, familial risk seemed to be increased slightly for women with high parity compared with women with low parity in the older age group, and seemed to be slightly decreased for women with high parity compared with women with low parity in younger women. The subject's age also appeared to have an effect on the interaction between familial risk and the age at first childbirth (P = 0.1). Conclusions. A possible influence of reproductive and menstrual factors on familial risk of BC has been suggested previously and was also evident in the present study. Three-way interactions between age, family history and parity or age at first childbirth might exist and they merit further investigation.

AB - Background. Studies have found that reproductive factors might have a variable effect on the occurence of breast cancer (BC) according to the existence or not of a family history of BC. The effect of a family history of BC on the risk of BC may also vary according to the age at diagnosis and the degree of kinship. This may confound the relation between familial risk and reproductive factors. A combined analysis was performed to study the interaction between familial risk and reproductive factors according to degree of familiality, age at interview and menopausal status. Methods. The present analysis included 2948 cases and 4170 controls in seven case-control studies from four countries. The combined relative risks were estimated using a Bayesian random-effects logistic regression model. Results. The main effects of reproductive life factors on the risk of BC are in agreement with previous studies. Two-way interactions between subject's age or menopausal status and a family history of BC were not significant. Although the three-way interaction between age, familial risk and parity was not significant, familial risk seemed to be increased slightly for women with high parity compared with women with low parity in the older age group, and seemed to be slightly decreased for women with high parity compared with women with low parity in younger women. The subject's age also appeared to have an effect on the interaction between familial risk and the age at first childbirth (P = 0.1). Conclusions. A possible influence of reproductive and menstrual factors on familial risk of BC has been suggested previously and was also evident in the present study. Three-way interactions between age, family history and parity or age at first childbirth might exist and they merit further investigation.

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