Variation in lung cancer risk by smoky coal subtype in Xuanwei, China

Qing Lan, Xingzhou He, Min Shen, Linwei Tian, Larry Z. Liu, Hong Lai, Wei Chen, Sonja I. Berndt, Howard D. Hosgood, Kyoung Mu Lee, Tongzhang Zheng, Aaron Blair, Robert S. Chapman

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Lung cancer rates in Xuanwei County have been among the highest in China for both males and females and have been causally associated with exposure to indoor smoky (bituminous) coal emissions that contain very high levels of polycyclic aromatic hydrocarbons. There are numerous coal mines across the County. Although lung cancer risk is strongly associated with the use of smoky coal as a whole, variation in risk by smoky coal subtype has not been characterized as yet. We conducted a population-based case-control study of 498 lung cancer cases and 498 controls, individually matched to case subjects on age (±2 years) and sex to examine risk by coal subtype. Odds ratios (ORs) and 95% confidence intervals (CIs) for coal subtype were calculated by conditional logistic regression, adjusting for potential confounders. Overall, smoky coal use was positively and statistically significantly associated with lung cancer risk, when compared with the use of smokeless coal or wood (OR = 7.7, 95% CI = 4.5-13.3). Furthermore, there was a marked heterogeneity in risk estimates for specific subtypes of smoky coal (test for heterogeneity: p = 5.17 × 10-10). Estimates were highest for coal of the Laibin (OR = 24.8, 95% CI = 12.4-49.6) and Longtan (OR = 11.6, 95% CI = 5.0-27.2) coal types and lower for coal from other subtypes. These findings strongly suggest that in Xuanwei and elsewhere, the carcinogenic potential of coal combustion products can exhibit substantial local variation by specific coal source.

Original languageEnglish (US)
Pages (from-to)2164-2169
Number of pages6
JournalInternational Journal of Cancer
Volume123
Issue number9
DOIs
StatePublished - Nov 1 2008
Externally publishedYes

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Coal
China
Lung Neoplasms
Odds Ratio
Confidence Intervals
Lobeline
Polycyclic Aromatic Hydrocarbons
Case-Control Studies

Keywords

  • China
  • Coal
  • Indoor air pollution
  • Lung cancer
  • Xuanwei

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Lan, Q., He, X., Shen, M., Tian, L., Liu, L. Z., Lai, H., ... Chapman, R. S. (2008). Variation in lung cancer risk by smoky coal subtype in Xuanwei, China. International Journal of Cancer, 123(9), 2164-2169. https://doi.org/10.1002/ijc.23748

Variation in lung cancer risk by smoky coal subtype in Xuanwei, China. / Lan, Qing; He, Xingzhou; Shen, Min; Tian, Linwei; Liu, Larry Z.; Lai, Hong; Chen, Wei; Berndt, Sonja I.; Hosgood, Howard D.; Lee, Kyoung Mu; Zheng, Tongzhang; Blair, Aaron; Chapman, Robert S.

In: International Journal of Cancer, Vol. 123, No. 9, 01.11.2008, p. 2164-2169.

Research output: Contribution to journalArticle

Lan, Q, He, X, Shen, M, Tian, L, Liu, LZ, Lai, H, Chen, W, Berndt, SI, Hosgood, HD, Lee, KM, Zheng, T, Blair, A & Chapman, RS 2008, 'Variation in lung cancer risk by smoky coal subtype in Xuanwei, China', International Journal of Cancer, vol. 123, no. 9, pp. 2164-2169. https://doi.org/10.1002/ijc.23748
Lan, Qing ; He, Xingzhou ; Shen, Min ; Tian, Linwei ; Liu, Larry Z. ; Lai, Hong ; Chen, Wei ; Berndt, Sonja I. ; Hosgood, Howard D. ; Lee, Kyoung Mu ; Zheng, Tongzhang ; Blair, Aaron ; Chapman, Robert S. / Variation in lung cancer risk by smoky coal subtype in Xuanwei, China. In: International Journal of Cancer. 2008 ; Vol. 123, No. 9. pp. 2164-2169.
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abstract = "Lung cancer rates in Xuanwei County have been among the highest in China for both males and females and have been causally associated with exposure to indoor smoky (bituminous) coal emissions that contain very high levels of polycyclic aromatic hydrocarbons. There are numerous coal mines across the County. Although lung cancer risk is strongly associated with the use of smoky coal as a whole, variation in risk by smoky coal subtype has not been characterized as yet. We conducted a population-based case-control study of 498 lung cancer cases and 498 controls, individually matched to case subjects on age (±2 years) and sex to examine risk by coal subtype. Odds ratios (ORs) and 95{\%} confidence intervals (CIs) for coal subtype were calculated by conditional logistic regression, adjusting for potential confounders. Overall, smoky coal use was positively and statistically significantly associated with lung cancer risk, when compared with the use of smokeless coal or wood (OR = 7.7, 95{\%} CI = 4.5-13.3). Furthermore, there was a marked heterogeneity in risk estimates for specific subtypes of smoky coal (test for heterogeneity: p = 5.17 × 10-10). Estimates were highest for coal of the Laibin (OR = 24.8, 95{\%} CI = 12.4-49.6) and Longtan (OR = 11.6, 95{\%} CI = 5.0-27.2) coal types and lower for coal from other subtypes. These findings strongly suggest that in Xuanwei and elsewhere, the carcinogenic potential of coal combustion products can exhibit substantial local variation by specific coal source.",
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AU - Lai, Hong

AU - Chen, Wei

AU - Berndt, Sonja I.

AU - Hosgood, Howard D.

AU - Lee, Kyoung Mu

AU - Zheng, Tongzhang

AU - Blair, Aaron

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AB - Lung cancer rates in Xuanwei County have been among the highest in China for both males and females and have been causally associated with exposure to indoor smoky (bituminous) coal emissions that contain very high levels of polycyclic aromatic hydrocarbons. There are numerous coal mines across the County. Although lung cancer risk is strongly associated with the use of smoky coal as a whole, variation in risk by smoky coal subtype has not been characterized as yet. We conducted a population-based case-control study of 498 lung cancer cases and 498 controls, individually matched to case subjects on age (±2 years) and sex to examine risk by coal subtype. Odds ratios (ORs) and 95% confidence intervals (CIs) for coal subtype were calculated by conditional logistic regression, adjusting for potential confounders. Overall, smoky coal use was positively and statistically significantly associated with lung cancer risk, when compared with the use of smokeless coal or wood (OR = 7.7, 95% CI = 4.5-13.3). Furthermore, there was a marked heterogeneity in risk estimates for specific subtypes of smoky coal (test for heterogeneity: p = 5.17 × 10-10). Estimates were highest for coal of the Laibin (OR = 24.8, 95% CI = 12.4-49.6) and Longtan (OR = 11.6, 95% CI = 5.0-27.2) coal types and lower for coal from other subtypes. These findings strongly suggest that in Xuanwei and elsewhere, the carcinogenic potential of coal combustion products can exhibit substantial local variation by specific coal source.

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