Variants in glucose- and circadian rhythm-related genes affect the response of energy expenditure to weight-loss diets

the POUNDS LOST Trial1-3

Khadijeh Mirzaei, Min Xu, Qibin Qi, Lilian De Jonge, George A. Bray, Frank Sacks, Lu Qi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Circadian rhythm has been shown to be related to glucose metabolism and risk of diabetes, probably through effects on energy balance. Recent genome-wide association studies identified variants in circadian rhythm-related genes (CRY2 and MTNR1B) associated with glucose homeostasis. Objective: We tested whether CRY2 and MTNR1B genotypes affected changes in measures of energy expenditure in response to a weight-loss diet intervention in a 2-y randomized clinical trial, the POUNDS (Preventing Overweight Using Novel Dietary Strategies) LOST Trial. Design: The variants CRY2 rs11605924 (n = 721) and MTNR1B rs10830963 (n = 722) were genotyped in overweight or obese adults who were randomly assigned to 1 of 4 weight-loss diets that differed in their proportions of macronutrients. Respiratory quotient (RQ) and resting metabolic rate (RMR) were measured. Results: By 2 y of diet intervention, the A allele of CRY2 rs11605924 was significantly associated with a greater reduction in RQ (P = 0.03) and a greater increase in RMR and RMR/kg (both P = 0.04). The G allele of MTNR1B rs10830963 was significantly associated with a greater increase in RQ (P = 0.01) but was not related to changes in RMR and RMR/kg. In addition, we found significant gene-diet fat interactions for both CRY2 (P-interaction = 0.02) and MTNR1B (P-interaction , 0.001) in relation to 2-y changes in RQ. Conclusions: Our data indicate that variants in the circadian-related genes CRY2 and MTNR1B may affect long-term changes in energy expenditure, and dietary fat intake may modify the genetic effects. This trial was registered at www.clinicaltrials.gov as NCT00072995.

Original languageEnglish (US)
Pages (from-to)392-399
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume99
Issue number2
DOIs
StatePublished - Feb 1 2014
Externally publishedYes

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Reducing Diet
Basal Metabolism
Circadian Rhythm
Energy Metabolism
Glucose
Genes
Alleles
Diet
Genome-Wide Association Study
Dietary Fats
Homeostasis
Randomized Controlled Trials
Fats
Genotype

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Variants in glucose- and circadian rhythm-related genes affect the response of energy expenditure to weight-loss diets : the POUNDS LOST Trial1-3. / Mirzaei, Khadijeh; Xu, Min; Qi, Qibin; De Jonge, Lilian; Bray, George A.; Sacks, Frank; Qi, Lu.

In: American Journal of Clinical Nutrition, Vol. 99, No. 2, 01.02.2014, p. 392-399.

Research output: Contribution to journalArticle

Mirzaei, Khadijeh ; Xu, Min ; Qi, Qibin ; De Jonge, Lilian ; Bray, George A. ; Sacks, Frank ; Qi, Lu. / Variants in glucose- and circadian rhythm-related genes affect the response of energy expenditure to weight-loss diets : the POUNDS LOST Trial1-3. In: American Journal of Clinical Nutrition. 2014 ; Vol. 99, No. 2. pp. 392-399.
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