Variant rs2200733 on chromosome 4q25 confers increased risk of atrial fibrillation: Evidence from a meta-analysis

Sanghamitra Mohanty, Pasquale Santangeli, Rong Bai, Luigi Di Biase, Prasant Mohanty, Agnes Pump, Andrea Natale

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Variant rs2200733 on Chromosome 4q25 Confers Increased Risk. Introduction: Several genome-wide association studies have identified rs2200733, a single-nucleotide polymorphism (SNP) at 4q25 to be the most common chromosomal variant present in patients with atrial fibrillation (AF). We aimed to explore the association of rs2200733 with AF through a systematic review and meta-analysis. Method: An extensive literature search was performed on PubMed, and other databases using the key words "genetics" and "AF." Seven case-control studies evaluating the association via multivariate analysis were identified including a total of 83,335 subjects (10,546 with AF, 72,789 referent individuals without AF). Meta-analytic estimates were derived using random effects models. Potential sources of heterogeneity were examined in sensitivity analyses, and publication biases were estimated. Result: At pooled analysis, there was a strong independent association between the variant rs2200733 and the risk of AF (OR 1.89 [95% CI 1.62-2.16], P < 0.001). Minor allelic frequencies for SNP rs22000733 were significantly more prevalent in AF population than non-AF. Metaregression results revealed that country of descent (logOR 0.38, P = 0.45) or site of study (logOR: -0.16, P = 0.41) did not moderate the overall effect size. Conclusion: Variant rs2200733 on chromosome 4q25 independently confers increased risk of AF. This finding will aid in improving our understanding of AF pathophysiology, risk prediction, and stratification of treatment strategy.

Original languageEnglish (US)
Pages (from-to)155-161
Number of pages7
JournalJournal of Cardiovascular Electrophysiology
Volume24
Issue number2
DOIs
StatePublished - Feb 2013
Externally publishedYes

Fingerprint

Atrial Fibrillation
Meta-Analysis
Chromosomes
Single Nucleotide Polymorphism
Publication Bias
Genome-Wide Association Study
PubMed
Case-Control Studies
Multivariate Analysis
Databases
Population

Keywords

  • 4q25
  • atrial fibrillation
  • chromosomal variant
  • rs2200733 SNP

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Variant rs2200733 on chromosome 4q25 confers increased risk of atrial fibrillation : Evidence from a meta-analysis. / Mohanty, Sanghamitra; Santangeli, Pasquale; Bai, Rong; Di Biase, Luigi; Mohanty, Prasant; Pump, Agnes; Natale, Andrea.

In: Journal of Cardiovascular Electrophysiology, Vol. 24, No. 2, 02.2013, p. 155-161.

Research output: Contribution to journalArticle

Mohanty, Sanghamitra ; Santangeli, Pasquale ; Bai, Rong ; Di Biase, Luigi ; Mohanty, Prasant ; Pump, Agnes ; Natale, Andrea. / Variant rs2200733 on chromosome 4q25 confers increased risk of atrial fibrillation : Evidence from a meta-analysis. In: Journal of Cardiovascular Electrophysiology. 2013 ; Vol. 24, No. 2. pp. 155-161.
@article{f3cfb33600894e778bc3b6f5dea044be,
title = "Variant rs2200733 on chromosome 4q25 confers increased risk of atrial fibrillation: Evidence from a meta-analysis",
abstract = "Variant rs2200733 on Chromosome 4q25 Confers Increased Risk. Introduction: Several genome-wide association studies have identified rs2200733, a single-nucleotide polymorphism (SNP) at 4q25 to be the most common chromosomal variant present in patients with atrial fibrillation (AF). We aimed to explore the association of rs2200733 with AF through a systematic review and meta-analysis. Method: An extensive literature search was performed on PubMed, and other databases using the key words {"}genetics{"} and {"}AF.{"} Seven case-control studies evaluating the association via multivariate analysis were identified including a total of 83,335 subjects (10,546 with AF, 72,789 referent individuals without AF). Meta-analytic estimates were derived using random effects models. Potential sources of heterogeneity were examined in sensitivity analyses, and publication biases were estimated. Result: At pooled analysis, there was a strong independent association between the variant rs2200733 and the risk of AF (OR 1.89 [95{\%} CI 1.62-2.16], P < 0.001). Minor allelic frequencies for SNP rs22000733 were significantly more prevalent in AF population than non-AF. Metaregression results revealed that country of descent (logOR 0.38, P = 0.45) or site of study (logOR: -0.16, P = 0.41) did not moderate the overall effect size. Conclusion: Variant rs2200733 on chromosome 4q25 independently confers increased risk of AF. This finding will aid in improving our understanding of AF pathophysiology, risk prediction, and stratification of treatment strategy.",
keywords = "4q25, atrial fibrillation, chromosomal variant, rs2200733 SNP",
author = "Sanghamitra Mohanty and Pasquale Santangeli and Rong Bai and {Di Biase}, Luigi and Prasant Mohanty and Agnes Pump and Andrea Natale",
year = "2013",
month = "2",
doi = "10.1111/jce.12017",
language = "English (US)",
volume = "24",
pages = "155--161",
journal = "Journal of Cardiovascular Electrophysiology",
issn = "1045-3873",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Variant rs2200733 on chromosome 4q25 confers increased risk of atrial fibrillation

T2 - Evidence from a meta-analysis

AU - Mohanty, Sanghamitra

AU - Santangeli, Pasquale

AU - Bai, Rong

AU - Di Biase, Luigi

AU - Mohanty, Prasant

AU - Pump, Agnes

AU - Natale, Andrea

PY - 2013/2

Y1 - 2013/2

N2 - Variant rs2200733 on Chromosome 4q25 Confers Increased Risk. Introduction: Several genome-wide association studies have identified rs2200733, a single-nucleotide polymorphism (SNP) at 4q25 to be the most common chromosomal variant present in patients with atrial fibrillation (AF). We aimed to explore the association of rs2200733 with AF through a systematic review and meta-analysis. Method: An extensive literature search was performed on PubMed, and other databases using the key words "genetics" and "AF." Seven case-control studies evaluating the association via multivariate analysis were identified including a total of 83,335 subjects (10,546 with AF, 72,789 referent individuals without AF). Meta-analytic estimates were derived using random effects models. Potential sources of heterogeneity were examined in sensitivity analyses, and publication biases were estimated. Result: At pooled analysis, there was a strong independent association between the variant rs2200733 and the risk of AF (OR 1.89 [95% CI 1.62-2.16], P < 0.001). Minor allelic frequencies for SNP rs22000733 were significantly more prevalent in AF population than non-AF. Metaregression results revealed that country of descent (logOR 0.38, P = 0.45) or site of study (logOR: -0.16, P = 0.41) did not moderate the overall effect size. Conclusion: Variant rs2200733 on chromosome 4q25 independently confers increased risk of AF. This finding will aid in improving our understanding of AF pathophysiology, risk prediction, and stratification of treatment strategy.

AB - Variant rs2200733 on Chromosome 4q25 Confers Increased Risk. Introduction: Several genome-wide association studies have identified rs2200733, a single-nucleotide polymorphism (SNP) at 4q25 to be the most common chromosomal variant present in patients with atrial fibrillation (AF). We aimed to explore the association of rs2200733 with AF through a systematic review and meta-analysis. Method: An extensive literature search was performed on PubMed, and other databases using the key words "genetics" and "AF." Seven case-control studies evaluating the association via multivariate analysis were identified including a total of 83,335 subjects (10,546 with AF, 72,789 referent individuals without AF). Meta-analytic estimates were derived using random effects models. Potential sources of heterogeneity were examined in sensitivity analyses, and publication biases were estimated. Result: At pooled analysis, there was a strong independent association between the variant rs2200733 and the risk of AF (OR 1.89 [95% CI 1.62-2.16], P < 0.001). Minor allelic frequencies for SNP rs22000733 were significantly more prevalent in AF population than non-AF. Metaregression results revealed that country of descent (logOR 0.38, P = 0.45) or site of study (logOR: -0.16, P = 0.41) did not moderate the overall effect size. Conclusion: Variant rs2200733 on chromosome 4q25 independently confers increased risk of AF. This finding will aid in improving our understanding of AF pathophysiology, risk prediction, and stratification of treatment strategy.

KW - 4q25

KW - atrial fibrillation

KW - chromosomal variant

KW - rs2200733 SNP

UR - http://www.scopus.com/inward/record.url?scp=84873407068&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873407068&partnerID=8YFLogxK

U2 - 10.1111/jce.12017

DO - 10.1111/jce.12017

M3 - Article

C2 - 23130627

AN - SCOPUS:84873407068

VL - 24

SP - 155

EP - 161

JO - Journal of Cardiovascular Electrophysiology

JF - Journal of Cardiovascular Electrophysiology

SN - 1045-3873

IS - 2

ER -