Abstract
Deep Brain Stimulation (DBS) is a neurosurgical procedure that can reduce symptoms in medically intractable obsessive-compulsive disorder (OCD). Conceptually, DBS of the ventral capsule/ventral striatum (VC/VS) region targets reciprocal excitatory connections between the orbitofrontal cortex (OFC) and thalamus, decreasing abnormal reverberant activity within the OFC-caudate-pallidal-thalamic circuit. In this study, we investigated these connections using diffusion magnetic resonance imaging (dMRI) on human connectome datasets of twenty-nine healthy young-adult volunteers with two-tensor unscented Kalman filter based tractography. We studied the morphology of the lateral and medial orbitofrontothalamic connections and estimated their topographic variability within the VC/VS region. Our results showed that the morphology of the individual orbitofrontothalamic fibers of passage in the VC/VS region is complex and inter-individual variability in their topography is high. We applied this method to an example OCD patient case who underwent DBS surgery, formulating an initial proof of concept for a tractography-guided patient-specific approach in DBS for medically intractable OCD. This may improve on current surgical practice, which involves implanting all patients at identical stereotactic coordinates within the VC/VS region.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1054-1067 |
| Number of pages | 14 |
| Journal | Brain Imaging and Behavior |
| Volume | 10 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1 2016 |
| Externally published | Yes |
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Keywords
- Connectome
- Deep brain stimulation (DBS)
- Diffusion tensor imaging
- Diffusion tractography
- Obsessive-compulsive disorder (OCD)
- Tractography-guided DBS
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Neurology
- Cognitive Neuroscience
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Psychiatry and Mental health
- Behavioral Neuroscience
Cite this
Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS) : precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD). / Makris, Nikolaos; Rathi, Yogesh; Mouradian, Palig; Bonmassar, Giorgio; Papadimitriou, George; Ing, Wingkwai I.; Yeterian, Edward H.; Kubicki, Marek; Eskandar, Emad N.; Wald, Lawrence L.; Fan, Qiuyun; Nummenmaa, Aapo; Widge, Alik S.; Dougherty, Darin D.
In: Brain Imaging and Behavior, Vol. 10, No. 4, 01.12.2016, p. 1054-1067.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS)
T2 - precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD)
AU - Makris, Nikolaos
AU - Rathi, Yogesh
AU - Mouradian, Palig
AU - Bonmassar, Giorgio
AU - Papadimitriou, George
AU - Ing, Wingkwai I.
AU - Yeterian, Edward H.
AU - Kubicki, Marek
AU - Eskandar, Emad N.
AU - Wald, Lawrence L.
AU - Fan, Qiuyun
AU - Nummenmaa, Aapo
AU - Widge, Alik S.
AU - Dougherty, Darin D.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Deep Brain Stimulation (DBS) is a neurosurgical procedure that can reduce symptoms in medically intractable obsessive-compulsive disorder (OCD). Conceptually, DBS of the ventral capsule/ventral striatum (VC/VS) region targets reciprocal excitatory connections between the orbitofrontal cortex (OFC) and thalamus, decreasing abnormal reverberant activity within the OFC-caudate-pallidal-thalamic circuit. In this study, we investigated these connections using diffusion magnetic resonance imaging (dMRI) on human connectome datasets of twenty-nine healthy young-adult volunteers with two-tensor unscented Kalman filter based tractography. We studied the morphology of the lateral and medial orbitofrontothalamic connections and estimated their topographic variability within the VC/VS region. Our results showed that the morphology of the individual orbitofrontothalamic fibers of passage in the VC/VS region is complex and inter-individual variability in their topography is high. We applied this method to an example OCD patient case who underwent DBS surgery, formulating an initial proof of concept for a tractography-guided patient-specific approach in DBS for medically intractable OCD. This may improve on current surgical practice, which involves implanting all patients at identical stereotactic coordinates within the VC/VS region.
AB - Deep Brain Stimulation (DBS) is a neurosurgical procedure that can reduce symptoms in medically intractable obsessive-compulsive disorder (OCD). Conceptually, DBS of the ventral capsule/ventral striatum (VC/VS) region targets reciprocal excitatory connections between the orbitofrontal cortex (OFC) and thalamus, decreasing abnormal reverberant activity within the OFC-caudate-pallidal-thalamic circuit. In this study, we investigated these connections using diffusion magnetic resonance imaging (dMRI) on human connectome datasets of twenty-nine healthy young-adult volunteers with two-tensor unscented Kalman filter based tractography. We studied the morphology of the lateral and medial orbitofrontothalamic connections and estimated their topographic variability within the VC/VS region. Our results showed that the morphology of the individual orbitofrontothalamic fibers of passage in the VC/VS region is complex and inter-individual variability in their topography is high. We applied this method to an example OCD patient case who underwent DBS surgery, formulating an initial proof of concept for a tractography-guided patient-specific approach in DBS for medically intractable OCD. This may improve on current surgical practice, which involves implanting all patients at identical stereotactic coordinates within the VC/VS region.
KW - Connectome
KW - Deep brain stimulation (DBS)
KW - Diffusion tensor imaging
KW - Diffusion tractography
KW - Obsessive-compulsive disorder (OCD)
KW - Tractography-guided DBS
UR - http://www.scopus.com/inward/record.url?scp=84945569038&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84945569038&partnerID=8YFLogxK
U2 - 10.1007/s11682-015-9462-9
DO - 10.1007/s11682-015-9462-9
M3 - Article
VL - 10
SP - 1054
EP - 1067
JO - Brain Imaging and Behavior
JF - Brain Imaging and Behavior
SN - 1931-7557
IS - 4
ER -