Validity of spiral analysis in Early Parkinson's disease

Rachel Saunders-Pullman, Carol A. Derby, Kaili Stanley, ALicia Floyd, Susan Bressman, Richard B. Lipton, Amanda Deligtisch, Lawrence Severt, Qiping Yu, Mónica Kurtis, Seth L. Pullman

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Spiral analysis is an objective, easy to administer noninvasive test that has been proposed to measure motor dysfunction in Parkinson disease (PD). We compared overall Unified Parkinson Disease Rating Scale Part III scores to selected indices derived from spiral analysis in seventy-four patients with early PD (mean duration of disease 2.4 ± 1.7 years, mean age 61.5 ± 9.7 years). Of the spiral indices, degree of severity, first order zero crossing, second order smoothness, and mean speed were best correlated with total motor Unified Parkinson's Disease Rating Scale (UPDRS) score (all P < 0.01), and these indices showed a gradient across worsening tertiles of UPDRS (P < 0.05). Spiral indices also correlated with UPDRS ratings for the worst side and worst arm scores as well. The domains of bradykinesia, rigidity, and action tremor were correlated with first order crossing, second order smoothness, and mean speed, where as rest tremor was most highly correlated with degree of severity. This suggests that the spiral analysis may supplement motor assessment in PD, although further analysis of spiral metrics, a larger sample and longitudinal data should be evaluated.

Original languageEnglish (US)
Pages (from-to)531-537
Number of pages7
JournalMovement Disorders
Volume23
Issue number4
DOIs
StatePublished - Mar 15 2008

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Parkinson Disease
Tremor
Hypokinesia

Keywords

  • Kinematics
  • Motor control
  • Parkinson disease
  • Spiral analysis
  • Upper limb

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Saunders-Pullman, R., Derby, C. A., Stanley, K., Floyd, AL., Bressman, S., Lipton, R. B., ... Pullman, S. L. (2008). Validity of spiral analysis in Early Parkinson's disease. Movement Disorders, 23(4), 531-537. https://doi.org/10.1002/mds.21874

Validity of spiral analysis in Early Parkinson's disease. / Saunders-Pullman, Rachel; Derby, Carol A.; Stanley, Kaili; Floyd, ALicia; Bressman, Susan; Lipton, Richard B.; Deligtisch, Amanda; Severt, Lawrence; Yu, Qiping; Kurtis, Mónica; Pullman, Seth L.

In: Movement Disorders, Vol. 23, No. 4, 15.03.2008, p. 531-537.

Research output: Contribution to journalArticle

Saunders-Pullman, R, Derby, CA, Stanley, K, Floyd, AL, Bressman, S, Lipton, RB, Deligtisch, A, Severt, L, Yu, Q, Kurtis, M & Pullman, SL 2008, 'Validity of spiral analysis in Early Parkinson's disease', Movement Disorders, vol. 23, no. 4, pp. 531-537. https://doi.org/10.1002/mds.21874
Saunders-Pullman R, Derby CA, Stanley K, Floyd AL, Bressman S, Lipton RB et al. Validity of spiral analysis in Early Parkinson's disease. Movement Disorders. 2008 Mar 15;23(4):531-537. https://doi.org/10.1002/mds.21874
Saunders-Pullman, Rachel ; Derby, Carol A. ; Stanley, Kaili ; Floyd, ALicia ; Bressman, Susan ; Lipton, Richard B. ; Deligtisch, Amanda ; Severt, Lawrence ; Yu, Qiping ; Kurtis, Mónica ; Pullman, Seth L. / Validity of spiral analysis in Early Parkinson's disease. In: Movement Disorders. 2008 ; Vol. 23, No. 4. pp. 531-537.
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