Validation of left ventricular end-diastolic volume from stroke volume and ejection fraction

Joseph P. Hart, Santos E. Cabreriza, Cecily G. Gallup, Daphne T. Hsu, Henry M. Spotnitz

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The present study examines an innovative approach to measurement of left ventricular (LV) end-diastolic volume (LVEDV). Measurement of LVEDV is fundamental to the assessment of intraoperative systolic and diastolic LV function. We compared steady state LVEDV values obtained from stroke volume (SV) and ejection fraction (EF) with echocardiographic and postmortem LVEDV measurements. Five anesthetized pigs (40-45 kg) underwent median sternotomy and pericardiotomy. A transit time ultrasonic flow probe was placed on the ascending aorta to provide cardiac output. A micromanometer provided LV end-diastolic pressure. LV short axis cross sectional echocardiograms and electrocardiograms were also obtained. LV end-diastolic area (LVEDA) and end-systolic area (LVESA) were measured to obtain EF. LVEDVsv/ef was calculated from cardiac output, heart rate, and EF. LVEDVecho was determined using a three-plane echocardiography model. Postmortem (LVEDVpmlvv) volumes were also measured. LVEDVsv/ef correlated well with volumes obtained by echocardiography (r2 = 0.92) and postmortem (r2 = 0.73) measurements. Values of p < 0.05 indicated significant linearity of LVEDA-LVEDVsv/ef (r2 =0.93), LVEDA-LVEDVecho (r2 = 0.96), and LVEDA-LVEDVpmlvv (r2 = 0.81) relationships. Determination of LVEDV from SV and EF is valid and may facilitate real-time determination of LV mechanics.

Original languageEnglish (US)
Pages (from-to)654-657
Number of pages4
JournalASAIO Journal
Volume48
Issue number6
StatePublished - Nov 2002
Externally publishedYes

Fingerprint

Stroke Volume
Echocardiography
Cardiac Output
Pericardiectomy
Volume measurement
Sternotomy
Mechanics
Electrocardiography
Left Ventricular Function
Ultrasonics
Aorta
Swine
Heart Rate
Blood Pressure

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering

Cite this

Hart, J. P., Cabreriza, S. E., Gallup, C. G., Hsu, D. T., & Spotnitz, H. M. (2002). Validation of left ventricular end-diastolic volume from stroke volume and ejection fraction. ASAIO Journal, 48(6), 654-657.

Validation of left ventricular end-diastolic volume from stroke volume and ejection fraction. / Hart, Joseph P.; Cabreriza, Santos E.; Gallup, Cecily G.; Hsu, Daphne T.; Spotnitz, Henry M.

In: ASAIO Journal, Vol. 48, No. 6, 11.2002, p. 654-657.

Research output: Contribution to journalArticle

Hart, JP, Cabreriza, SE, Gallup, CG, Hsu, DT & Spotnitz, HM 2002, 'Validation of left ventricular end-diastolic volume from stroke volume and ejection fraction', ASAIO Journal, vol. 48, no. 6, pp. 654-657.
Hart, Joseph P. ; Cabreriza, Santos E. ; Gallup, Cecily G. ; Hsu, Daphne T. ; Spotnitz, Henry M. / Validation of left ventricular end-diastolic volume from stroke volume and ejection fraction. In: ASAIO Journal. 2002 ; Vol. 48, No. 6. pp. 654-657.
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