Vaccine efficacy of a lysine auxotroph of Mycobacterium tuberculosis

Martin S. Pavelka; Bing Chen; Cynthia L. Kelley; Frank M. Collins; William R. Jacobs

doi:10.1128/IAI.71.7.4190-4192.2003

Vaccine efficacy of a lysine auxotroph of Mycobacterium tuberculosis

Martin S. Pavelka, Bing Chen, Cynthia L. Kelley, Frank M. Collins, William R. Jacobs

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

The in vivo growth phenotype and vaccine efficacy of a lysine auxotrophic mutant of Mycobacterium tuberculosis strain H37Rv are described. An immunization experiment using a mouse model with an aerosol challenge showed that two doses of the M. tuberculosis mutant were required to generate protection equivalent to that of the Mycobacterium bovis BCG vaccine.

Original language	English (US)
Pages (from-to)	4190-4192
Number of pages	3
Journal	Infection and immunity
Volume	71
Issue number	7
DOIs	https://doi.org/10.1128/IAI.71.7.4190-4192.2003
State	Published - Jul 1 2003
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/IAI.71.7.4190-4192.2003

Cite this

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abstract = "The in vivo growth phenotype and vaccine efficacy of a lysine auxotrophic mutant of Mycobacterium tuberculosis strain H37Rv are described. An immunization experiment using a mouse model with an aerosol challenge showed that two doses of the M. tuberculosis mutant were required to generate protection equivalent to that of the Mycobacterium bovis BCG vaccine.",

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AU - Kelley, Cynthia L.

AU - Collins, Frank M.

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AB - The in vivo growth phenotype and vaccine efficacy of a lysine auxotrophic mutant of Mycobacterium tuberculosis strain H37Rv are described. An immunization experiment using a mouse model with an aerosol challenge showed that two doses of the M. tuberculosis mutant were required to generate protection equivalent to that of the Mycobacterium bovis BCG vaccine.

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Vaccine efficacy of a lysine auxotroph of Mycobacterium tuberculosis

Abstract

ASJC Scopus subject areas

UN SDGs

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