The in vivo growth phenotype and vaccine efficacy of a lysine auxotrophic mutant of Mycobacterium tuberculosis strain H37Rv are described. An immunization experiment using a mouse model with an aerosol challenge showed that two doses of the M. tuberculosis mutant were required to generate protection equivalent to that of the Mycobacterium bovis BCG vaccine.
|Original language||English (US)|
|Number of pages||3|
|Journal||Infection and immunity|
|State||Published - Jul 1 2003|
ASJC Scopus subject areas
- Infectious Diseases