Utilization of voriconazole drug monitoring in the treatment of cutaneous Scedosporium apiospermum infection

McKenna E. Boyd, Harry Dao, Jerry D. Estep, Yve T. Huttenbach, Vagish Hemmige

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We report the use of voriconazole troughs to achieve appropriate therapeutic levels in treatment of a cutaneous Scedosporium apiospermum infection. Following heart transplantation, a 63-year-old immunocompromised patient presented with post-traumatic nodular lesions on his right shin. Pathology showed fungal yeasts with culture revealing Scedosporium apiospermum. According to therapeutic drug monitoring, initial voriconazole treatment was subtherapeutic requiring increased dosing until appropriate therapeutic trough levels were attained, and resolution of the fungal infection was achieved.

Original languageEnglish (US)
Pages (from-to)52-54
Number of pages3
JournalMedical Mycology Case Reports
Volume22
DOIs
StatePublished - Dec 1 2018

Fingerprint

Scedosporium
Drug Monitoring
Skin
Mycoses
Immunocompromised Host
Heart Transplantation
Infection
Yeasts
Pathology
Therapeutics
Voriconazole

Keywords

  • Cutaneous Scedosporium apiospermum
  • Immunocompromised
  • Transplant
  • Trough
  • Voriconazole

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

Cite this

Utilization of voriconazole drug monitoring in the treatment of cutaneous Scedosporium apiospermum infection. / Boyd, McKenna E.; Dao, Harry; Estep, Jerry D.; Huttenbach, Yve T.; Hemmige, Vagish.

In: Medical Mycology Case Reports, Vol. 22, 01.12.2018, p. 52-54.

Research output: Contribution to journalArticle

Boyd, McKenna E. ; Dao, Harry ; Estep, Jerry D. ; Huttenbach, Yve T. ; Hemmige, Vagish. / Utilization of voriconazole drug monitoring in the treatment of cutaneous Scedosporium apiospermum infection. In: Medical Mycology Case Reports. 2018 ; Vol. 22. pp. 52-54.
@article{68e21a3c08f144be8bd231ce0e4b08cc,
title = "Utilization of voriconazole drug monitoring in the treatment of cutaneous Scedosporium apiospermum infection",
abstract = "We report the use of voriconazole troughs to achieve appropriate therapeutic levels in treatment of a cutaneous Scedosporium apiospermum infection. Following heart transplantation, a 63-year-old immunocompromised patient presented with post-traumatic nodular lesions on his right shin. Pathology showed fungal yeasts with culture revealing Scedosporium apiospermum. According to therapeutic drug monitoring, initial voriconazole treatment was subtherapeutic requiring increased dosing until appropriate therapeutic trough levels were attained, and resolution of the fungal infection was achieved.",
keywords = "Cutaneous Scedosporium apiospermum, Immunocompromised, Transplant, Trough, Voriconazole",
author = "Boyd, {McKenna E.} and Harry Dao and Estep, {Jerry D.} and Huttenbach, {Yve T.} and Vagish Hemmige",
year = "2018",
month = "12",
day = "1",
doi = "10.1016/j.mmcr.2018.09.002",
language = "English (US)",
volume = "22",
pages = "52--54",
journal = "Medical Mycology Case Reports",
issn = "2211-7539",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Utilization of voriconazole drug monitoring in the treatment of cutaneous Scedosporium apiospermum infection

AU - Boyd, McKenna E.

AU - Dao, Harry

AU - Estep, Jerry D.

AU - Huttenbach, Yve T.

AU - Hemmige, Vagish

PY - 2018/12/1

Y1 - 2018/12/1

N2 - We report the use of voriconazole troughs to achieve appropriate therapeutic levels in treatment of a cutaneous Scedosporium apiospermum infection. Following heart transplantation, a 63-year-old immunocompromised patient presented with post-traumatic nodular lesions on his right shin. Pathology showed fungal yeasts with culture revealing Scedosporium apiospermum. According to therapeutic drug monitoring, initial voriconazole treatment was subtherapeutic requiring increased dosing until appropriate therapeutic trough levels were attained, and resolution of the fungal infection was achieved.

AB - We report the use of voriconazole troughs to achieve appropriate therapeutic levels in treatment of a cutaneous Scedosporium apiospermum infection. Following heart transplantation, a 63-year-old immunocompromised patient presented with post-traumatic nodular lesions on his right shin. Pathology showed fungal yeasts with culture revealing Scedosporium apiospermum. According to therapeutic drug monitoring, initial voriconazole treatment was subtherapeutic requiring increased dosing until appropriate therapeutic trough levels were attained, and resolution of the fungal infection was achieved.

KW - Cutaneous Scedosporium apiospermum

KW - Immunocompromised

KW - Transplant

KW - Trough

KW - Voriconazole

UR - http://www.scopus.com/inward/record.url?scp=85053790136&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053790136&partnerID=8YFLogxK

U2 - 10.1016/j.mmcr.2018.09.002

DO - 10.1016/j.mmcr.2018.09.002

M3 - Article

AN - SCOPUS:85053790136

VL - 22

SP - 52

EP - 54

JO - Medical Mycology Case Reports

JF - Medical Mycology Case Reports

SN - 2211-7539

ER -