Uterine sarcoma with ambiguous histomorphology: A case report

Eirwen M. Miller; Yumei Fu; Ruben Barrera Vera; Gary L. Goldberg; Rouzan G. Karabakhtsian

doi:10.1016/j.gore.2017.02.006

Uterine sarcoma with ambiguous histomorphology: A case report

Eirwen M. Miller, Yumei Fu, Ruben Barrera Vera, Gary L. Goldberg, Rouzan G. Karabakhtsian

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background Leiomyosarcomas (LMS) and endometrial stromal sarcomas (ESS) may display overlapping histomorphology, which may challenge diagnostic accuracy. Since LMS and ESS have vastly different clinical behavior and adjuvant therapy recommendations, accurate diagnosis is critical. Case We present the case of an 83-year-old female with postmenopausal bleeding who underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy for clinically atypical appearing leiomyomata. Histologically, dual populations of cells with morphologic features of low-grade ESS and high-grade spindle cell sarcoma were seen. Immunohistochemistry and molecular studies revealed the cells to be of smooth muscle derivation, rendering a diagnosis of high-grade LMS with heterogeneous morphology (stage IB). The patient received adjuvant gemcitabine plus docetaxel. She recurred 8 months after completion of chemotherapy and was transferred to hospice care. Conclusion Ancillary studies, such as immunohistochemistry and molecular testing, aid in accurate subcategorization of uterine sarcomas with ambiguous histomorphology.

Original language	English (US)
Pages (from-to)	30-33
Number of pages	4
Journal	Gynecologic Oncology Reports
Volume	20
DOIs	https://doi.org/10.1016/j.gore.2017.02.006
State	Published - May 1 2017

Keywords

Endometrial stromal sarcoma
Histomorphology
Immunohistochemistry
Leiomyosarcoma
Molecular testing
Uterine sarcoma

ASJC Scopus subject areas

Oncology
Obstetrics and Gynecology

Access to Document

10.1016/j.gore.2017.02.006

Cite this

@article{99f3876bcd434157a4604cda9f9008a8,

title = "Uterine sarcoma with ambiguous histomorphology: A case report",

abstract = "Background Leiomyosarcomas (LMS) and endometrial stromal sarcomas (ESS) may display overlapping histomorphology, which may challenge diagnostic accuracy. Since LMS and ESS have vastly different clinical behavior and adjuvant therapy recommendations, accurate diagnosis is critical. Case We present the case of an 83-year-old female with postmenopausal bleeding who underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy for clinically atypical appearing leiomyomata. Histologically, dual populations of cells with morphologic features of low-grade ESS and high-grade spindle cell sarcoma were seen. Immunohistochemistry and molecular studies revealed the cells to be of smooth muscle derivation, rendering a diagnosis of high-grade LMS with heterogeneous morphology (stage IB). The patient received adjuvant gemcitabine plus docetaxel. She recurred 8 months after completion of chemotherapy and was transferred to hospice care. Conclusion Ancillary studies, such as immunohistochemistry and molecular testing, aid in accurate subcategorization of uterine sarcomas with ambiguous histomorphology.",

keywords = "Endometrial stromal sarcoma, Histomorphology, Immunohistochemistry, Leiomyosarcoma, Molecular testing, Uterine sarcoma",

author = "Miller, {Eirwen M.} and Yumei Fu and Vera, {Ruben Barrera} and Goldberg, {Gary L.} and Karabakhtsian, {Rouzan G.}",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors",

year = "2017",

month = may,

day = "1",

doi = "10.1016/j.gore.2017.02.006",

language = "English (US)",

volume = "20",

pages = "30--33",

journal = "Gynecologic Oncology Reports",

issn = "2211-338X",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Uterine sarcoma with ambiguous histomorphology

T2 - A case report

AU - Miller, Eirwen M.

AU - Fu, Yumei

AU - Vera, Ruben Barrera

AU - Goldberg, Gary L.

AU - Karabakhtsian, Rouzan G.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Background Leiomyosarcomas (LMS) and endometrial stromal sarcomas (ESS) may display overlapping histomorphology, which may challenge diagnostic accuracy. Since LMS and ESS have vastly different clinical behavior and adjuvant therapy recommendations, accurate diagnosis is critical. Case We present the case of an 83-year-old female with postmenopausal bleeding who underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy for clinically atypical appearing leiomyomata. Histologically, dual populations of cells with morphologic features of low-grade ESS and high-grade spindle cell sarcoma were seen. Immunohistochemistry and molecular studies revealed the cells to be of smooth muscle derivation, rendering a diagnosis of high-grade LMS with heterogeneous morphology (stage IB). The patient received adjuvant gemcitabine plus docetaxel. She recurred 8 months after completion of chemotherapy and was transferred to hospice care. Conclusion Ancillary studies, such as immunohistochemistry and molecular testing, aid in accurate subcategorization of uterine sarcomas with ambiguous histomorphology.

AB - Background Leiomyosarcomas (LMS) and endometrial stromal sarcomas (ESS) may display overlapping histomorphology, which may challenge diagnostic accuracy. Since LMS and ESS have vastly different clinical behavior and adjuvant therapy recommendations, accurate diagnosis is critical. Case We present the case of an 83-year-old female with postmenopausal bleeding who underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy for clinically atypical appearing leiomyomata. Histologically, dual populations of cells with morphologic features of low-grade ESS and high-grade spindle cell sarcoma were seen. Immunohistochemistry and molecular studies revealed the cells to be of smooth muscle derivation, rendering a diagnosis of high-grade LMS with heterogeneous morphology (stage IB). The patient received adjuvant gemcitabine plus docetaxel. She recurred 8 months after completion of chemotherapy and was transferred to hospice care. Conclusion Ancillary studies, such as immunohistochemistry and molecular testing, aid in accurate subcategorization of uterine sarcomas with ambiguous histomorphology.

KW - Endometrial stromal sarcoma

KW - Histomorphology

KW - Immunohistochemistry

KW - Leiomyosarcoma

KW - Molecular testing

KW - Uterine sarcoma

UR - http://www.scopus.com/inward/record.url?scp=85013651428&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85013651428&partnerID=8YFLogxK

U2 - 10.1016/j.gore.2017.02.006

DO - 10.1016/j.gore.2017.02.006

M3 - Article

AN - SCOPUS:85013651428

SN - 2211-338X

VL - 20

SP - 30

EP - 33

JO - Gynecologic Oncology Reports

JF - Gynecologic Oncology Reports

ER -

Uterine sarcoma with ambiguous histomorphology: A case report

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this