Using the deadly μ-conotoxins as probes of voltage-gated sodium channels

Ronald A. Li, Gordon F. Tomaselli

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

μ-Conotoxins (μ-CTX) are potent Na channel inhibitory peptides isolated from the venom of the predatory marine snail Conus geographus. μ-CTXs exert their biological action by physically occluding the ion-conducting pore of voltage-gated Na (Nav) channels with a 1:1 stoichiometry in an all-or-none fashion. This article reviews our current knowledge of the mechanism of μ-CTX and the associated structural and functional insights into its molecular target - Nav channels.

Original languageEnglish (US)
Pages (from-to)117-122
Number of pages6
JournalToxicon
Volume44
Issue number2
DOIs
StatePublished - Aug 2004
Externally publishedYes

Keywords

  • Na channel
  • Pore
  • μ-Conotoxin

ASJC Scopus subject areas

  • Toxicology

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