Using the deadly μ-conotoxins as probes of voltage-gated sodium channels

Ronald A. Li, Gordon F. Tomaselli

Research output: Contribution to journalShort survey

38 Citations (Scopus)

Abstract

μ-Conotoxins (μ-CTX) are potent Na channel inhibitory peptides isolated from the venom of the predatory marine snail Conus geographus. μ-CTXs exert their biological action by physically occluding the ion-conducting pore of voltage-gated Na (Nav) channels with a 1:1 stoichiometry in an all-or-none fashion. This article reviews our current knowledge of the mechanism of μ-CTX and the associated structural and functional insights into its molecular target - Nav channels.

Original languageEnglish (US)
Pages (from-to)117-122
Number of pages6
JournalToxicon
Volume44
Issue number2
DOIs
StatePublished - Aug 1 2004
Externally publishedYes

Fingerprint

Conotoxins
Voltage-Gated Sodium Channels
Conus Snail
Venoms
Stoichiometry
Ions
Peptides
Electric potential

Keywords

  • μ-Conotoxin
  • Na channel
  • Pore

ASJC Scopus subject areas

  • Toxicology

Cite this

Using the deadly μ-conotoxins as probes of voltage-gated sodium channels. / Li, Ronald A.; Tomaselli, Gordon F.

In: Toxicon, Vol. 44, No. 2, 01.08.2004, p. 117-122.

Research output: Contribution to journalShort survey

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