Using point process models to compare neural spiking activity in the subthalamic nucleus of parkinsons patients and a healthy primate

Sridevi V. Sarma, Uri T. Eden, Ming L. Cheng, Ziv M. Williams, Rollin Hu, Emad Eskandar, Emery N. Brown

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Placement of deep brain stimulating electrodes in the subthalamic nucleus (STN) to treat Parkinsons disease (PD) also allows the recording of single neuron spiking activity. Analyses of these unique data offer an important opportunity to better understand the pathophysiology of PD. Despite the point process nature of PD neural spiking activity, point process methods are rarely used to analyze these recordings. We develop a point process representation of PD neural spiking activity using a generalized linear model to describe long- and short-term temporal dependencies in the spiking activity of 28 STN neurons from seven PD patients and 35 neurons from one healthy primate (surrogate control) recorded, while the subjects executed a directed-hand movement task. We used the point process model to characterize each neurons bursting, oscillatory, and directional tuning properties during key periods in the task trial. Relative to the control neurons, the PD neurons showed increased bursting, increased 1030 Hz oscillations, and increased fluctuations in directional tuning. These features, which traditional methods failed to capture accurately, were efficiently summarized in a single model in the point process analysis of each neuron. The point process framework suggests a useful approach for developing quantitative neural correlates that may be related directly to the movement and behavioral disorders characteristic of PD.

Original languageEnglish (US)
Article number5415596
Pages (from-to)1297-1305
Number of pages9
JournalIEEE Transactions on Biomedical Engineering
Volume57
Issue number6
DOIs
StatePublished - Jun 1 2010
Externally publishedYes

Keywords

  • Deep brain stimulation (DBS)
  • Parkinson's disease (PD)
  • Point processes
  • Spike trains

ASJC Scopus subject areas

  • Biomedical Engineering

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