Using CRISPR to inactivate endogenous retroviruses in pigs: an important step toward safe xenotransplantation?

Michael J. Ross, P. Toby Coates

Research output: Contribution to journalComment/debate

4 Scopus citations


Xenotransplantation could theoretically provide an unlimited supply of organs for patients living with end-stage kidney disease and other end-stage organ failure, but severe rejection and concerns about possible transmission of zoonotic infections remain important obstacles. In a recent study, investigators used CRISPR-cas9 to generate genetically modified pigs in which all endogenous retroviruses were inactivated. This approach may address one important barrier to the feasibility of clinical trials of xenotransplantation.

Original languageEnglish (US)
Pages (from-to)4-6
Number of pages3
JournalKidney international
Issue number1
StatePublished - Jan 2018



  • gene expression
  • gene therapy
  • microbiology

ASJC Scopus subject areas

  • Nephrology

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