Use of 18F-fluorodeoxyglucose positron emission tomography-computed tomography to aid in diagnosing intestinal adenocarcinoma in 2 rhesus macaques (Macaca mulatta)

Debra J. Caporizzo, Anna E. Kwiatkowski, Ming Kai Chen, Amanda P. Beck, Carmen J. Booth, Caroline Zeiss, Peter C. Smith, Jodi A. Carlson Scholz, Steven R. Wilson

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Abstract

Two aged female rhesus macaques (Macaca mulatta) presented with weight loss and intermittent inappetence. The signalment and constellation of clinical signs led clinicians to suspect the presence of intestinal adenocarcinoma. Because of each animal's advanced age and inconclusive radiographic findings, a noninvasive diagnostic tool was preferred over exploratory laparotomy to assist in determining a diagnosis. Consequently, 2-[18F]fluoro-2-deoxy-d- glucose (FDG) positron emission tomography-CT (FDG-PET-CT) was chosen to aid in confirming a suspicion of gastrointestinal adenocarcinoma in both animals. FDG is a glucose analogue labeled with fluorine-18 and is taken up by highly metabolically active cells, as observed in many cancers. Tomography revealed an annular constriction of the small intestine with focal FDG uptake in one animal, and an FDG avid transmural mass in the ascending colon of the second animal. Necropsy later confirmed both sites to be adenocarcinomas. This report supports the use of FDG-PET-CT as an adjunct to conventional radiography in the diagnosis of intestinal adenocarcinoma in nonhuman primates.

Original languageEnglish (US)
Pages (from-to)211-220
Number of pages10
JournalComparative Medicine
Volume64
Issue number3
StatePublished - Jun 2014
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

Cite this

Caporizzo, D. J., Kwiatkowski, A. E., Chen, M. K., Beck, A. P., Booth, C. J., Zeiss, C., Smith, P. C., Carlson Scholz, J. A., & Wilson, S. R. (2014). Use of 18F-fluorodeoxyglucose positron emission tomography-computed tomography to aid in diagnosing intestinal adenocarcinoma in 2 rhesus macaques (Macaca mulatta). Comparative Medicine, 64(3), 211-220.