Use of strain imaging in detecting segmental dysfunction in patients with hypertrophic cardiomyopathy

Hua Yang, Jing Ping Sun, Harry M. Lever, Zoran B. Popovic, Jeanne K. Drinko, Neil L. Greenberg, Takahiro Shiota, James D. Thomas, Mario J. Garcia

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Background: The distribution and magnitude of left ventricular hypertrophy are not uniform in patients with hypertrophic cardiomyopathy (HCM). Previous echocardiographic studies have focused on global left ventricular function. Recently, myocardial Doppler strain (ε) imaging, a newly developed technique, has allowed the quantification of regional myocardial motion. The aim of this study was to characterize regional left ventricular systolic function by myocardial Doppler ε imaging in patients with HCM. Methods: Included in this study were 31 patients with asymmetric septal hypertrophy and HCM, and 41 age-matched healthy patients. Regional longitudinal axial systolic ε was assessed at the basal, mid, and apical segments of the septal and lateral walls and compared between both groups. Results: Patients with HCM had reduced ε at the ventricular septum (-10.3 ± 5.7%) compared with control patients (-19.4 ± 3.3%, P < .001). In the HCM group, ε in the midseptum (-1.3 ± 8.2%) was significantly less than at the basal (- 12.2 ± 8.7%, P < .01) and apical septum (-17.3 ± 10.4%, P < .01), and was also less than at the midlateral wall (-9.4 ± 5.3%, P < .05). There was a significant correlation between midseptal ε and intraventricular septum to posterior wall thickness ratio (r = 0.81, P < .001). Conclusion: Midseptal longitudinal ε was markedly decreased, even reversed in patients with HCM (paradoxic longitudinal systolic expansion), which was directly related to the degree of septal hypertrophy. Myocardial Doppler ε imaging could offer a unique approach to quantify regional systolic dysfunction in these patients.

Original languageEnglish (US)
Pages (from-to)233-239
Number of pages7
JournalJournal of the American Society of Echocardiography
Volume16
Issue number3
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

Fingerprint

Hypertrophic Cardiomyopathy
Left Ventricular Function
Hypertrophy
Ventricular Septum
Left Ventricular Hypertrophy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Use of strain imaging in detecting segmental dysfunction in patients with hypertrophic cardiomyopathy. / Yang, Hua; Sun, Jing Ping; Lever, Harry M.; Popovic, Zoran B.; Drinko, Jeanne K.; Greenberg, Neil L.; Shiota, Takahiro; Thomas, James D.; Garcia, Mario J.

In: Journal of the American Society of Echocardiography, Vol. 16, No. 3, 01.03.2003, p. 233-239.

Research output: Contribution to journalArticle

Yang, Hua ; Sun, Jing Ping ; Lever, Harry M. ; Popovic, Zoran B. ; Drinko, Jeanne K. ; Greenberg, Neil L. ; Shiota, Takahiro ; Thomas, James D. ; Garcia, Mario J. / Use of strain imaging in detecting segmental dysfunction in patients with hypertrophic cardiomyopathy. In: Journal of the American Society of Echocardiography. 2003 ; Vol. 16, No. 3. pp. 233-239.
@article{3ad2b17caa6143c4b137e6384f39936b,
title = "Use of strain imaging in detecting segmental dysfunction in patients with hypertrophic cardiomyopathy",
abstract = "Background: The distribution and magnitude of left ventricular hypertrophy are not uniform in patients with hypertrophic cardiomyopathy (HCM). Previous echocardiographic studies have focused on global left ventricular function. Recently, myocardial Doppler strain (ε) imaging, a newly developed technique, has allowed the quantification of regional myocardial motion. The aim of this study was to characterize regional left ventricular systolic function by myocardial Doppler ε imaging in patients with HCM. Methods: Included in this study were 31 patients with asymmetric septal hypertrophy and HCM, and 41 age-matched healthy patients. Regional longitudinal axial systolic ε was assessed at the basal, mid, and apical segments of the septal and lateral walls and compared between both groups. Results: Patients with HCM had reduced ε at the ventricular septum (-10.3 ± 5.7{\%}) compared with control patients (-19.4 ± 3.3{\%}, P < .001). In the HCM group, ε in the midseptum (-1.3 ± 8.2{\%}) was significantly less than at the basal (- 12.2 ± 8.7{\%}, P < .01) and apical septum (-17.3 ± 10.4{\%}, P < .01), and was also less than at the midlateral wall (-9.4 ± 5.3{\%}, P < .05). There was a significant correlation between midseptal ε and intraventricular septum to posterior wall thickness ratio (r = 0.81, P < .001). Conclusion: Midseptal longitudinal ε was markedly decreased, even reversed in patients with HCM (paradoxic longitudinal systolic expansion), which was directly related to the degree of septal hypertrophy. Myocardial Doppler ε imaging could offer a unique approach to quantify regional systolic dysfunction in these patients.",
author = "Hua Yang and Sun, {Jing Ping} and Lever, {Harry M.} and Popovic, {Zoran B.} and Drinko, {Jeanne K.} and Greenberg, {Neil L.} and Takahiro Shiota and Thomas, {James D.} and Garcia, {Mario J.}",
year = "2003",
month = "3",
day = "1",
doi = "10.1067/mje.2003.60",
language = "English (US)",
volume = "16",
pages = "233--239",
journal = "Journal of the American Society of Echocardiography",
issn = "0894-7317",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - Use of strain imaging in detecting segmental dysfunction in patients with hypertrophic cardiomyopathy

AU - Yang, Hua

AU - Sun, Jing Ping

AU - Lever, Harry M.

AU - Popovic, Zoran B.

AU - Drinko, Jeanne K.

AU - Greenberg, Neil L.

AU - Shiota, Takahiro

AU - Thomas, James D.

AU - Garcia, Mario J.

PY - 2003/3/1

Y1 - 2003/3/1

N2 - Background: The distribution and magnitude of left ventricular hypertrophy are not uniform in patients with hypertrophic cardiomyopathy (HCM). Previous echocardiographic studies have focused on global left ventricular function. Recently, myocardial Doppler strain (ε) imaging, a newly developed technique, has allowed the quantification of regional myocardial motion. The aim of this study was to characterize regional left ventricular systolic function by myocardial Doppler ε imaging in patients with HCM. Methods: Included in this study were 31 patients with asymmetric septal hypertrophy and HCM, and 41 age-matched healthy patients. Regional longitudinal axial systolic ε was assessed at the basal, mid, and apical segments of the septal and lateral walls and compared between both groups. Results: Patients with HCM had reduced ε at the ventricular septum (-10.3 ± 5.7%) compared with control patients (-19.4 ± 3.3%, P < .001). In the HCM group, ε in the midseptum (-1.3 ± 8.2%) was significantly less than at the basal (- 12.2 ± 8.7%, P < .01) and apical septum (-17.3 ± 10.4%, P < .01), and was also less than at the midlateral wall (-9.4 ± 5.3%, P < .05). There was a significant correlation between midseptal ε and intraventricular septum to posterior wall thickness ratio (r = 0.81, P < .001). Conclusion: Midseptal longitudinal ε was markedly decreased, even reversed in patients with HCM (paradoxic longitudinal systolic expansion), which was directly related to the degree of septal hypertrophy. Myocardial Doppler ε imaging could offer a unique approach to quantify regional systolic dysfunction in these patients.

AB - Background: The distribution and magnitude of left ventricular hypertrophy are not uniform in patients with hypertrophic cardiomyopathy (HCM). Previous echocardiographic studies have focused on global left ventricular function. Recently, myocardial Doppler strain (ε) imaging, a newly developed technique, has allowed the quantification of regional myocardial motion. The aim of this study was to characterize regional left ventricular systolic function by myocardial Doppler ε imaging in patients with HCM. Methods: Included in this study were 31 patients with asymmetric septal hypertrophy and HCM, and 41 age-matched healthy patients. Regional longitudinal axial systolic ε was assessed at the basal, mid, and apical segments of the septal and lateral walls and compared between both groups. Results: Patients with HCM had reduced ε at the ventricular septum (-10.3 ± 5.7%) compared with control patients (-19.4 ± 3.3%, P < .001). In the HCM group, ε in the midseptum (-1.3 ± 8.2%) was significantly less than at the basal (- 12.2 ± 8.7%, P < .01) and apical septum (-17.3 ± 10.4%, P < .01), and was also less than at the midlateral wall (-9.4 ± 5.3%, P < .05). There was a significant correlation between midseptal ε and intraventricular septum to posterior wall thickness ratio (r = 0.81, P < .001). Conclusion: Midseptal longitudinal ε was markedly decreased, even reversed in patients with HCM (paradoxic longitudinal systolic expansion), which was directly related to the degree of septal hypertrophy. Myocardial Doppler ε imaging could offer a unique approach to quantify regional systolic dysfunction in these patients.

UR - http://www.scopus.com/inward/record.url?scp=0037355064&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037355064&partnerID=8YFLogxK

U2 - 10.1067/mje.2003.60

DO - 10.1067/mje.2003.60

M3 - Article

C2 - 12618731

AN - SCOPUS:0037355064

VL - 16

SP - 233

EP - 239

JO - Journal of the American Society of Echocardiography

JF - Journal of the American Society of Echocardiography

SN - 0894-7317

IS - 3

ER -