Use of positron emission tomography to target prostate cancer gene therapy by oncolytic herpes simplex virus

Michael Mullerad, David P. Eisenberg, Timothy J. Akhurst, Prasad S. Adusumilli, Christopher C. Riedl, Amit Bhargava, Mithat Gonen, Ronald Finn, Peter T. Scardino, Yuman Fong

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Herpes simplex virus (HSV) oncolytic gene therapy is a promising treatment modality against cancer. We have demonstrated that androgen-induced cellular changes enhance oncolytic viral replication and improve efficacy in the treatment of androgen-dependent prostate cancer cell line. Imaging of changes in 2-deoxy-2-[F-18]fluoro-d-glucose (FDG) uptake by positron emission tomography (PET) is a sensitive method of detecting altered cellular metabolism involved in cancer therapy. We therefore hypothesized that FDG-PET can predict tumor response to oncolytic HSV therapy. In this study, androgen increased cell kill (74%) in vitro and enhanced viral yield (2.4-fold) in vivo following HSV therapy. This enhanced efficacy was predicted by high FDG accumulation in intact animals compared to low FDG uptake following orchiectomy (p = 0.002). This proof-of-concept study provides the mechanistic basis for selecting patients for targeted oncolytic viral therapy by means of a noninvasive molecular imaging method in the treatment of prostate cancer.

Original languageEnglish (US)
Pages (from-to)30-35
Number of pages6
JournalMolecular Imaging and Biology
Volume8
Issue number1
DOIs
StatePublished - Jan 2006

Keywords

  • Fluorodeoxyglucose
  • Herpes virus
  • Hormonal therapy
  • Prediction

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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    Mullerad, M., Eisenberg, D. P., Akhurst, T. J., Adusumilli, P. S., Riedl, C. C., Bhargava, A., Gonen, M., Finn, R., Scardino, P. T., & Fong, Y. (2006). Use of positron emission tomography to target prostate cancer gene therapy by oncolytic herpes simplex virus. Molecular Imaging and Biology, 8(1), 30-35. https://doi.org/10.1007/s11307-005-0028-x