Abstract
Study Objectives: The aim was to assess the relationship between continuous positive airway pressure (CPAP) therapy and cognitive function in patients with mild cognitive impairment (MCI) and obstructive sleep apnea (OSA). Methods: This was a retrospective chart reviewof patientswithMCI andOSA.CPAP therapy compliance was defined as average use ofCPAP therapy for at least 4 hours per night. Kaplan-Meier estimates, log-rank tests, and Cox proportional hazards regression were done to compare the compliance groups in terms of progression to dementia, defined as a Clinical Dementia Rating of 1 or greater. Linear mixed models were used to assess the relationships between CPAP therapy compliance and neurological cognitive function outcomes over time. Results: Ninety-six patients were included with mean age at MCI diagnosis of 70.4 years, mean apnea-hypopnea index of 25.9 events/h, and mean duration of neurology follow-up of 2.8 years. Forty-two were CPAP compliant, 30 were noncompliant, and 24 had no CPAP use. No overall difference between the groups was detected for progression to dementia (P =.928, log-rank test). Patients with amnestic MCI had better CPAP use (P =.016) and shorter progression time to dementia (P = .042), but this difference was not significant after adjusting for age, education, and race (P = .32). Conclusions: CPAP use in patients with MCI and OSA was not associated with delay in progression to dementia or cognitive decline.
Original language | English (US) |
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Pages (from-to) | 863-870 |
Number of pages | 8 |
Journal | Journal of Clinical Sleep Medicine |
Volume | 16 |
Issue number | 6 |
DOIs | |
State | Published - Jun 15 2020 |
Externally published | Yes |
Keywords
- Continuous positive airway pressure
- Dementia
- Mild cognitive impairment
- Sleep apnea
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Neurology
- Clinical Neurology