Use of pentoxifylline as an inhibitor of free radical generation in peripheral vascular disease - Results of a double-blind placebo-controlled study

G. Ciuffetti, M. Mercuri, C. Ott, R. Lombardini, R. Paltriccia, G. Lupattelli, Laura Santambrogio, E. Mannarino

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The effects of an infusion of pentoxifylline 1 g as an inhibitor of free radical generation have been determined in a double-blind placebo-controlled study. Leucocyte-derived free radical generation (by the superoxide dismutase-inhibitable reduction of ferricytochrome), the release of reactive oxygen metabolites (as plasma oxidant activity), unfractionated leucocyte and erythrocyte filterability rates (using a constant-flow positive-pressure system), plasma viscosity, and plasma fibrinogen concentration have been measured in two matched groups of 10 patients with Stage II peripheral vascular disease, before and after treatment. Transcutaneous oxygen pressure (PtcO2) during treadmill exercise to stress leg circulation was also measured. Leucocyte-derived free radicals were generated during peripheral ischaemia. Pentoxifylline inhibited their generation, blocked the release of reactive oxygen metabolites, and reduced impairment of the filterability rate of unfractionated leucocytes. The improvements were accompanied by significant shortening of the half-time of recovery of transcutaneous oxygen pressure, indicating that ischaemic damage had been contained.

Original languageEnglish (US)
Pages (from-to)511-515
Number of pages5
JournalEuropean Journal of Clinical Pharmacology
Volume41
Issue number6
DOIs
StatePublished - Dec 1991
Externally publishedYes

Fingerprint

Pentoxifylline
Peripheral Vascular Diseases
Free Radicals
Leukocytes
Placebos
Oxygen
Pressure
Transcutaneous Blood Gas Monitoring
Erythrocyte Deformability
Oxidants
Viscosity
Fibrinogen
Superoxide Dismutase
Leg
Research Design
Ischemia
Exercise
Therapeutics

Keywords

  • adverse effects
  • Free radical generation
  • Pentoxifylline
  • peripheral vascular disease

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

Use of pentoxifylline as an inhibitor of free radical generation in peripheral vascular disease - Results of a double-blind placebo-controlled study. / Ciuffetti, G.; Mercuri, M.; Ott, C.; Lombardini, R.; Paltriccia, R.; Lupattelli, G.; Santambrogio, Laura; Mannarino, E.

In: European Journal of Clinical Pharmacology, Vol. 41, No. 6, 12.1991, p. 511-515.

Research output: Contribution to journalArticle

Ciuffetti, G. ; Mercuri, M. ; Ott, C. ; Lombardini, R. ; Paltriccia, R. ; Lupattelli, G. ; Santambrogio, Laura ; Mannarino, E. / Use of pentoxifylline as an inhibitor of free radical generation in peripheral vascular disease - Results of a double-blind placebo-controlled study. In: European Journal of Clinical Pharmacology. 1991 ; Vol. 41, No. 6. pp. 511-515.
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