Use of molecular biomarkers in FNA specimens to personalize treatment for thyroid surgery

Vikas Mehta, Yuri E. Nikiforov, Robert L. Ferris

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Accurate preoperative assessment of thyroid nodules with fine-needle aspiration biopsy (FNAB) continues to be a challenge, often resulting in unnecessary diagnostic surgical intervention. The detection of several novel gene mutations in differentiated thyroid cancer (DTC) over the last decade has led to the diagnostic use of these oncogenic alterations to improve FNAB sensitivity and specificity. Methods and Results: Thyroid oncogene mutations including BRAF, RAS, and RET/PTC are reviewed. The potential benefit of using this panel on fine-needle aspiration (FNA) cytology samples will be described. Conclusion: Our use of ''reflexive'' molecular testing demonstrates its clinical value in conjunction with FNAB cytology, representing an application of personalized molecular medicine to guide appropriate surgical therapy.

Original languageEnglish (US)
Pages (from-to)1499-1506
Number of pages8
JournalHead and Neck
Volume35
Issue number10
DOIs
StatePublished - Oct 2013
Externally publishedYes

Fingerprint

Fine Needle Biopsy
Thyroid Gland
Biomarkers
Cell Biology
Molecular Medicine
Precision Medicine
Mutation
Thyroid Nodule
Factor IX
Therapeutics
Oncogenes
Thyroid Neoplasms
Sensitivity and Specificity
Genes

Keywords

  • biomarkers
  • diagnosis
  • molecular testing
  • prognosis
  • Thyroid

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Use of molecular biomarkers in FNA specimens to personalize treatment for thyroid surgery. / Mehta, Vikas; Nikiforov, Yuri E.; Ferris, Robert L.

In: Head and Neck, Vol. 35, No. 10, 10.2013, p. 1499-1506.

Research output: Contribution to journalArticle

Mehta, Vikas ; Nikiforov, Yuri E. ; Ferris, Robert L. / Use of molecular biomarkers in FNA specimens to personalize treatment for thyroid surgery. In: Head and Neck. 2013 ; Vol. 35, No. 10. pp. 1499-1506.
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