Use of ethotoin in phenytoin-related hypersensitivity reactions

Alan B. Ettinger; Solomon L. Moshé; Mark J. Sinnett; Juan C. Canton; Shlomo Shinnar

doi:10.1016/S0896-6974(05)80007-6

Use of ethotoin in phenytoin-related hypersensitivity reactions

Alan B. Ettinger, Solomon L. Moshé, Mark J. Sinnett, Juan C. Canton, Shlomo Shinnar

Neurology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Hypersensitivity reactions to phenytoin (PHT) usually result in abandoning the use of hydantoin compounds in the treatment of epilepsy. We report two cases of patients experiencing allergic reactions to PHT who were successfully switched to a related phenylhydantoin, ethotoin, and who remained free of hypersensitivity reactions. Potential mechanisms for differences in hypersensitivity are discussed.

Original language	English (US)
Pages (from-to)	29-31
Number of pages	3
Journal	Journal of Epilepsy
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/S0896-6974(05)80007-6
State	Published - 1993

Keywords

Anticonvulsants
Ethotoin
Hypersensitivity
Phenylhydantoin

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology

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10.1016/S0896-6974(05)80007-6

Cite this

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abstract = "Hypersensitivity reactions to phenytoin (PHT) usually result in abandoning the use of hydantoin compounds in the treatment of epilepsy. We report two cases of patients experiencing allergic reactions to PHT who were successfully switched to a related phenylhydantoin, ethotoin, and who remained free of hypersensitivity reactions. Potential mechanisms for differences in hypersensitivity are discussed.",

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AU - Ettinger, Alan B.

AU - Moshé, Solomon L.

AU - Sinnett, Mark J.

AU - Canton, Juan C.

AU - Shinnar, Shlomo

PY - 1993

Y1 - 1993

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AB - Hypersensitivity reactions to phenytoin (PHT) usually result in abandoning the use of hydantoin compounds in the treatment of epilepsy. We report two cases of patients experiencing allergic reactions to PHT who were successfully switched to a related phenylhydantoin, ethotoin, and who remained free of hypersensitivity reactions. Potential mechanisms for differences in hypersensitivity are discussed.

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KW - Ethotoin

KW - Hypersensitivity

KW - Phenylhydantoin

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Use of ethotoin in phenytoin-related hypersensitivity reactions

Abstract

Keywords

ASJC Scopus subject areas

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