Hypersensitivity reactions to phenytoin (PHT) usually result in abandoning the use of hydantoin compounds in the treatment of epilepsy. We report two cases of patients experiencing allergic reactions to PHT who were successfully switched to a related phenylhydantoin, ethotoin, and who remained free of hypersensitivity reactions. Potential mechanisms for differences in hypersensitivity are discussed.
ASJC Scopus subject areas
- Clinical Neurology