Use of cerebral organoids to model environmental and gene x environment interactions in the developing fetus and neurodegenerative disorders

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The developing fetus, while generally safe from the outside world, is often exposed to any one of a number of toxins, drugs, infectious microbes, and maternal antibodies and cytokines that adversely affect the developing brain. This can have life-long consequences on cognitive function and behavior. Cerebral organoids derived from induced pluripotent stem cells (iPSCs) are used as a model system to study the first trimester brain, providing researchers with an opportunity to identify underlying molecular pathways that are disrupted by potentially dangerous environmental exposures. In addition, using patient-specific iPSCs allows researchers to study gene x environment interactions. Such studies could lead to the development of novel therapies for at-risk fetuses.

Original languageEnglish (US)
Title of host publicationPhenotyping of Human iPSC-derived Neurons
Subtitle of host publicationPatient-Driven Research
PublisherElsevier
Pages173-200
Number of pages28
ISBN (Electronic)9780128222775
ISBN (Print)9780128222782
DOIs
StatePublished - Jan 1 2022

Keywords

  • Cerebral organoids
  • COVID-19
  • Gene x environment
  • HIV
  • Induced pluripotent stem cell
  • Maternal immune activation
  • Midbrain organoids
  • Neurodegenerative
  • Neurodevelopmental

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Use of cerebral organoids to model environmental and gene x environment interactions in the developing fetus and neurodegenerative disorders'. Together they form a unique fingerprint.

Cite this