Use of angiotensin-converting enzyme inhibitors as monotherapy and in combination with diuretics and calcium channel blockers

Angela Cheng, William H. Frishman

Research output: Contribution to journalReview article

11 Scopus citations


Angiotensin-converting enzyme (ACE) inhibitors have earned an important place in medical therapy since their discovery about two decades ago. This family of drug has grown tremendously since the introduction of captopril in 1981. There are currently more than 14 ACE inhibitors in the world and 9 are available in the United States. Although these agents share many similarities, they differ in their pharmacokinetic properties, approved indications, and cost. This paper provides guidance for selection of ACE inhibitors by examining the pharmacokinetics, pharmacodynamics, drug interactions, adverse effects, and cost of these agents. Combination products of ACE inhibitors with either diuretics or calcium channel blockers also are reviewed.

Original languageEnglish (US)
Pages (from-to)477-491
Number of pages15
JournalJournal of Clinical Pharmacology
Issue number6
Publication statusPublished - Jun 1998


ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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