Urokinase receptor and integrin partnership: Coordination of signaling for cell adhesion, migration and growth

Liliana Ossowski, Julio A. Aguirre-Ghiso

Research output: Contribution to journalReview articlepeer-review

355 Scopus citations

Abstract

Urokinase-type plasminogen activator receptor (uPAR) binds the urokinase-type plasminogen activator (uPA) and facilitates a proteolytic cascade focused at the cell surface. More recently, uPAR was recognized as a multifunctional protein that, through its interactions with integrins, initiates signaling events that alter cell adhesion, migration and proliferation. Results obtained recently have led to new insights into the structural aspects of uPAR interaction with integrins, provided a more detailed description of the signaling pathway they induce, and determined that uPAR signaling plays a role in cell migration and tumorigenicity.

Original languageEnglish (US)
Pages (from-to)613-620
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume12
Issue number5
DOIs
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

Fingerprint

Dive into the research topics of 'Urokinase receptor and integrin partnership: Coordination of signaling for cell adhesion, migration and growth'. Together they form a unique fingerprint.

Cite this