Urinary neutrophil gelatinase-associated lipocalin is a promising biomarker for late onset culture-positive sepsis in very low birth weight infants

Elvira Parravicini, Sheri L. Nemerofsky, Kenneth A. Michelson, Trang K. Huynh, Meghan E. Sise, David A. Bateman, John M. Lorenz, Jonathan M. Barasch

Research output: Contribution to journalArticle

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Abstract

Need for the early identification of sepsis in very low birth weight (VLBW) infants has led to the search for reliable biomarkers. This study aims to determine whether urinary neutrophil gelatinase-associated lipocalin (uNGAL) rises in culture-positive sepsis and, if so, is elevated at the time sepsis is suspected. This is a prospective study of 91 VLBW infants whose urine was collected daily for uNGAL analysis. In 65 episodes of suspected sepsis, four groups were identified: a) culture-positive sepsis; b) single culture positive for Staphylococcus epidermidis; c) and d) negative culture with antibiotic treatment for ≥7 d and <7 d, respectively. Daily means of uNGAL of each group were estimated for comparison. Mean uNGAL in group A (179 ng/mL) was significantly elevated on the day blood culture was drawn (day 0) compared with the mean of healthy VLBW infants (6.5 ng/mL), and to the means in groups B, C, and D (p < 0.05). In group A, mean uNGAL was significantly elevated on day 0 and daily for 5 days when compared with that of the day before culture (p < 0.05 to <0.005). uNGAL shows promise as an early marker for culture-positive sepsis in VLBW infants.

Original languageEnglish (US)
Pages (from-to)636-640
Number of pages5
JournalPediatric Research
Volume67
Issue number6
DOIs
StatePublished - Jun 2010

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Very Low Birth Weight Infant
Sepsis
Biomarkers
Staphylococcus epidermidis
Lipocalin-2
Urine
Prospective Studies
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Urinary neutrophil gelatinase-associated lipocalin is a promising biomarker for late onset culture-positive sepsis in very low birth weight infants. / Parravicini, Elvira; Nemerofsky, Sheri L.; Michelson, Kenneth A.; Huynh, Trang K.; Sise, Meghan E.; Bateman, David A.; Lorenz, John M.; Barasch, Jonathan M.

In: Pediatric Research, Vol. 67, No. 6, 06.2010, p. 636-640.

Research output: Contribution to journalArticle

Parravicini, Elvira ; Nemerofsky, Sheri L. ; Michelson, Kenneth A. ; Huynh, Trang K. ; Sise, Meghan E. ; Bateman, David A. ; Lorenz, John M. ; Barasch, Jonathan M. / Urinary neutrophil gelatinase-associated lipocalin is a promising biomarker for late onset culture-positive sepsis in very low birth weight infants. In: Pediatric Research. 2010 ; Vol. 67, No. 6. pp. 636-640.
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