Urethral adenocarcinoma associated with intestinal-type metaplasia, case report and literature review

Christopher S. Hale, Hongying Huang, Jonathan Melamed, Ruliang Xu, Larry Roberts, Rosemary Wieczorek, Zhiheng Pei, Peng Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Abstract: The presence of glandular epithelium in urinary tract biopsies poses a diagnostic challenge. Intestinal metaplasia of the urethra may be seen in many congenital, iatrogenic, and reactive conditions, as well as in association with malignant conditions such as urethral adenocarcinoma. We present a case of a 61 year-old woman presenting with microscopic hematuria. Successive biopsies showed glandular epithelium with focal atypia in close association with inflammation, but no overt malignancy. Only on surgical resection was the associated high grade adenocarcinoma revealed. When intestinal-type mucosa is present within a urinary tract biopsy, associated malignancy may be present only focally. Thorough sampling and consideration of the differential diagnosis is imperative.

Original languageEnglish (US)
Pages (from-to)1665-1670
Number of pages6
JournalInternational Journal of Clinical and Experimental Pathology
Volume6
Issue number8
StatePublished - 2013
Externally publishedYes

Fingerprint

Metaplasia
Adenocarcinoma
Biopsy
Urothelium
Hematuria
Urethra
Intestinal Mucosa
Urinary Tract
Neoplasms
Differential Diagnosis
Epithelium
Inflammation

Keywords

  • intestinal metaplasia
  • Urethral adenocarcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Hale, C. S., Huang, H., Melamed, J., Xu, R., Roberts, L., Wieczorek, R., ... Lee, P. (2013). Urethral adenocarcinoma associated with intestinal-type metaplasia, case report and literature review. International Journal of Clinical and Experimental Pathology, 6(8), 1665-1670.

Urethral adenocarcinoma associated with intestinal-type metaplasia, case report and literature review. / Hale, Christopher S.; Huang, Hongying; Melamed, Jonathan; Xu, Ruliang; Roberts, Larry; Wieczorek, Rosemary; Pei, Zhiheng; Lee, Peng.

In: International Journal of Clinical and Experimental Pathology, Vol. 6, No. 8, 2013, p. 1665-1670.

Research output: Contribution to journalArticle

Hale, CS, Huang, H, Melamed, J, Xu, R, Roberts, L, Wieczorek, R, Pei, Z & Lee, P 2013, 'Urethral adenocarcinoma associated with intestinal-type metaplasia, case report and literature review', International Journal of Clinical and Experimental Pathology, vol. 6, no. 8, pp. 1665-1670.
Hale, Christopher S. ; Huang, Hongying ; Melamed, Jonathan ; Xu, Ruliang ; Roberts, Larry ; Wieczorek, Rosemary ; Pei, Zhiheng ; Lee, Peng. / Urethral adenocarcinoma associated with intestinal-type metaplasia, case report and literature review. In: International Journal of Clinical and Experimental Pathology. 2013 ; Vol. 6, No. 8. pp. 1665-1670.
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