TY - JOUR
T1 - Urethral adenocarcinoma associated with intestinal-type metaplasia, case report and literature review
AU - Hale, Christopher S.
AU - Huang, Hongying
AU - Melamed, Jonathan
AU - Xu, Ruliang
AU - Roberts, Larry
AU - Wieczorek, Rosemary
AU - Pei, Zhiheng
AU - Lee, Peng
PY - 2013
Y1 - 2013
N2 - Abstract: The presence of glandular epithelium in urinary tract biopsies poses a diagnostic challenge. Intestinal metaplasia of the urethra may be seen in many congenital, iatrogenic, and reactive conditions, as well as in association with malignant conditions such as urethral adenocarcinoma. We present a case of a 61 year-old woman presenting with microscopic hematuria. Successive biopsies showed glandular epithelium with focal atypia in close association with inflammation, but no overt malignancy. Only on surgical resection was the associated high grade adenocarcinoma revealed. When intestinal-type mucosa is present within a urinary tract biopsy, associated malignancy may be present only focally. Thorough sampling and consideration of the differential diagnosis is imperative.
AB - Abstract: The presence of glandular epithelium in urinary tract biopsies poses a diagnostic challenge. Intestinal metaplasia of the urethra may be seen in many congenital, iatrogenic, and reactive conditions, as well as in association with malignant conditions such as urethral adenocarcinoma. We present a case of a 61 year-old woman presenting with microscopic hematuria. Successive biopsies showed glandular epithelium with focal atypia in close association with inflammation, but no overt malignancy. Only on surgical resection was the associated high grade adenocarcinoma revealed. When intestinal-type mucosa is present within a urinary tract biopsy, associated malignancy may be present only focally. Thorough sampling and consideration of the differential diagnosis is imperative.
KW - Urethral adenocarcinoma
KW - intestinal metaplasia
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M3 - Article
C2 - 23923086
AN - SCOPUS:84882959074
SN - 1936-2625
VL - 6
SP - 1665
EP - 1670
JO - International Journal of Clinical and Experimental Pathology
JF - International Journal of Clinical and Experimental Pathology
IS - 8
ER -